⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15358714 | 0.71 | — | — | |
| SCHEMBL15109119 | 0.71 | — | — | |
| SCHEMBL15499989 | 0.71 | — | — | |
| SCHEMBL8957114 | 0.67 | — | — | |
| SCHEMBL17770697 | 0.65 | — | — | |
| SCHEMBL1038811 | 0.65 | — | — | |
| SCHEMBL1561675 | 0.65 | — | — | |
| SCHEMBL612525 | 0.63 | TSHR (0.38) | — | |
| SCHEMBL15112 | 0.63 | — | — | |
| Hydrochloric Acid SCHEMBL3889714 | 0.63 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10835578-B2 | CNP prodrugs with large carrier moieties | ASCENDIS PHARMA GROWTH DISORDERS A/S (DK) | 2020-11-17 | — | — | US | disclosed |
| US-20190328840-A1 | CONTROLLED-RELEASE CNP AGONISTS WITH LOW INITIAL NPR-B ACTIVITY | ASCENDIS PHARMA GROWTH DISORDERS A/S (DK) | 2019-10-31 | — | — | US | disclosed |
| US-20190015481-A1 | CNP PRODRUGS WITH LARGE CARRIER MOIETIES | ASCENDIS PHARMA GROWTH DISORDERS A/S (DK) | 2019-01-17 | — | — | US | disclosed |
| US-20190008977-A1 | CNP PRODRUGS WITH CARRIER ATTACHMENT AT THE RING MOIETY | ASCENDIS PHARMA GROWTH DISORDERS A/S (DK) | 2019-01-10 | — | — | US | disclosed |
| EP-2741778-A1 | POLYMERIC HYPERBRANCHED CARRIER-LINKED PRODRUGS | Ascendis Pharma A/S (DK) | 2014-06-18 | — | — | EP | disclosed |
| WO-2013024048-A1 | POLYMERIC HYPERBRANCHED CARRIER-LINKED PRODRUGS | ASCENDIS PHARMA A/S (DK) | 2013-02-21 | — | — | WO | disclosed |
| EP-2485767-A1 | CARRIER LINKED PALIPERIDONE PRODRUGS | Ascendis Pharma A/S (DK) | 2012-08-15 | — | — | EP | disclosed |
| WO-2011042450-A1 | CARRIER LINKED PALIPERIDONE PRODRUGS | ASCENDIS PHARMA AS (DK) | 2011-04-14 | — | — | WO | disclosed |