Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.40 |
| ▸ | HTR7 | P34969 | 3/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.38 |
| ▸ | KDM4A | O75164 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | HTR1B | P28222 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 3/20 | 0.36 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.36 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1154662 | 1.00 | HTR2C (0.46) | HTR2CHTR2APIN1CHRM4HTR7 | |
| SCHEMBL22143619 | 0.89 | HTR2A (0.44) | HTR2CHTR2APIN1KDM4AKDM4C | |
| SCHEMBL1265569 | 0.89 | HTR2A (0.44) | HTR2CHTR2APIN1KDM4AKDM4C | |
| SCHEMBL6025431 | 0.89 | HTR2A (0.44) | HTR2CHTR2APIN1KDM4AKDM4C | |
| SCHEMBL16363092 | 0.84 | SRD5A1 (0.45) | HTR2CHTR2APIN1IDO1DRD2 | |
| SCHEMBL1745527 | 0.84 | SRD5A1 (0.45) | HTR2CHTR2APIN1IDO1DRD2 | |
| SCHEMBL16363081 | 0.84 | SRD5A1 (0.45) | HTR2CHTR2APIN1IDO1DRD2 | |
| SCHEMBL16821224 | 0.81 | ESR2 (0.46) | HTR2CCHRM4HTR7DRD2 | |
| SCHEMBL8348394 | 0.78 | ESR1 (0.54) | DRD2SLC6A4 | |
| SCHEMBL28033988 | 0.78 | ESR1 (0.54) | DRD2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2861231-B1 | INHIBITOR OF JAK1 AND JAK2 | LILLY CO ELI (US) | 2016-08-31 | — | — | EP | disclosed |
| EP-2861231-B1 | INHIBITOR OF JAK1 AND JAK2 | LILLY CO ELI (US) | 2016-08-31 | — | — | EP | disclosed |
| US-9062050-B2 | Inhibitor of JAK1 and JAK2 | ELI LILLY AND COMPANY (US) | 2015-06-23 | — | — | US | disclosed |
| US-9062050-B2 | Inhibitor of JAK1 and JAK2 | ELI LILLY AND COMPANY (US) | 2015-06-23 | — | — | US | disclosed |
| US-9062050-B2 | Inhibitor of JAK1 and JAK2 | ELI LILLY AND COMPANY (US) | 2015-06-23 | — | — | US | disclosed |
| US-20150133490-A1 | INHIBITOR OF JAK1 AND JAK2 | ELI LILLY AND COMPANY | 2015-05-14 | — | — | US | disclosed |
| US-20150133490-A1 | INHIBITOR OF JAK1 AND JAK2 | ELI LILLY AND COMPANY | 2015-05-14 | — | — | US | disclosed |
| US-20150133490-A1 | INHIBITOR OF JAK1 AND JAK2 | ELI LILLY AND COMPANY | 2015-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150133490-A1 | INHIBITOR OF JAK1 AND JAK2 | JAK1, JAK2, JAK3 | HTR2C 1721/4885HTR2A 3217/4885PIN1 1392/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.