Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.35 |
| ▸ | LMNA | P02545 | 5/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 2/20 | 0.33 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | ATAD2 | Q6PL18 | 2/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12637619 | 0.79 | ALDH1A1 (0.37) | MAPTALDH1A1 | |
| SCHEMBL3999191 | 0.71 | MAPT (0.44) | MAPTKDM4ERAD52ALDH1A1LMNA | |
| SCHEMBL3360819 | 0.68 | MAPT (0.44) | MAPTKDM4ERAD52ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL31174158 | 0.67 | MAPT (0.44) | MAPTKDM4ERAD52ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL28709952 | 0.67 | MAPT (0.44) | MAPTKDM4ERAD52ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL27970719 | 0.67 | MAPT (0.44) | MAPTKDM4ERAD52ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL29386046 | 0.67 | MAPT (0.44) | MAPTKDM4ERAD52ALDH1A1LMNA | |
| SCHEMBL520908 | 0.67 | BRD4 (0.51) | MAPTKDM4ERAD52ALDH1A1ADRA2C | |
| SCHEMBL29240610 | 0.66 | MAPT (0.45) | MAPTKDM4EALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL10511110 | 0.64 | DRD1 (0.44) | MAPTKDM4ELMNAHTTDRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486009-A1 | 2H-PYRROL-5-AMINE DERIVATIVES AS ALPHA ADRENERGIC RECEPTOR MODULATORS | Allergan, Inc. (US) | 2012-08-15 | — | — | EP | disclosed |
| WO-2011044229-A1 | 2H-PYRROL-5-AMINE DERIVATIVES AS ALPHA ADRENERGIC RECEPTOR MODULATORS | ALLERGAN, INC. (US) | 2011-04-14 | — | — | WO | disclosed |