SCHEMBL167007

SCHEMBL167007

O=C(O)CN1CCC(O)CC1

nearest known ligand 0.64

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 1/20 0.50
USP2 O75604 1/20 0.42
ALDH1A1 P00352 1/20 0.42
KCNA3 P22001 1/20 0.39
ITGB3 P05106 2/20 0.38
ITGA2B P08514 2/20 0.38
ARG1 P05089 2/20 0.37
ARG2 P78540 2/20 0.37
ALOX15 P16050 1/20 0.37
TERT O14746 1/20 0.36
ACE P12821 1/20 0.36
SLC6A9 P48067 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL873652 0.86 HSD17B10 (0.42) HSD17B10ALDH1A1KCNA3
SCHEMBL167637 0.86 HSD17B10 (0.42) HSD17B10ALDH1A1KCNA3
SCHEMBL873557 0.86 HSD17B10 (0.42) HSD17B10ALDH1A1KCNA3
SCHEMBL23291292 0.81 HSD17B10 (0.56) HSD17B10ALDH1A1ITGB3ITGA2BALOX15
SCHEMBL26986921 0.81 HSD17B10 (0.50) HSD17B10ALDH1A1ITGB3ITGA2BALOX15
SCHEMBL8902965 0.81 USP2 (0.42) USP2ALDH1A1KCNA3ARG1ARG2
SCHEMBL16228133 0.81 HSD17B10 (0.50) HSD17B10ALDH1A1ITGB3ITGA2BALOX15
SCHEMBL835266 0.79 HTT (0.50) HSD17B10ALDH1A1
SCHEMBL12640379 0.79 ALDH1A1 (0.41) USP2ALDH1A1KCNA3TERT
SCHEMBL6215711 0.79 HSD17B10 (0.48) HSD17B10ITGB3ITGA2BALOX15ACE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 70 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102656179-A Bufalin derivatives, pharmaceutical compositions and uses thereof SUZHOU NEUPHARMA CO LTD 2012-09-05 CN claimed
WO-2012027957-A1 BUFALIN DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND USE THEREOF SUZHOU NEUPHARMA CO., LTD. (CN) 2012-03-08 WO claimed
CN-1777427-A Aminoheteroaryl compounds as protein kinase inhibitors SUGEN INC (US) 2006-05-24 CN claimed
US-20260076982-A1 Prodrugs of Cannbidiol [CBD]-Type Phytocannabinoids and a Process for Preparation Thereof COUNCIL SCIENT IND RES (IN) 2026-03-19 US disclosed
EP-4551241-A1 PRODRUGS OF CANNBIDIOL [CBD]-TYPE PHYTOCANNABINOIDS AND A PROCESS FOR PREPARATION THEREOF Council of Scientific & Industrial Research (IN) 2025-05-14 EP disclosed
US-20250057852-A1 BICYCLIC HETEROCYCLES AS FGFR INHIBITORS INCYTE CORPORATION 2025-02-20 US disclosed
US-12083124-B2 Bicyclic heterocycles as FGFR inhibitors INCYTE CORPORATION (US) 2024-09-10 US disclosed
WO-2024009324-A1 PRODRUGS OF CANNBIDIOL [CBD]-TYPE PHYTOCANNABINOIDS AND A PROCESS FOR PREPARATION THEREOF COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2024-01-11 WO disclosed
WO-2024009324-A1 PRODRUGS OF CANNBIDIOL [CBD]-TYPE PHYTOCANNABINOIDS AND A PROCESS FOR PREPARATION THEREOF COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2024-01-11 WO disclosed
US-20230338389-A1 BICYCLIC HETEROCYCLES AS FGFR INHIBITORS INCYTE CORPORATION 2023-10-26 US disclosed
WO-2023051628-A1 SOS1 INHIBITORS HAVING PYRIDO SIX-MEMBERED RING STRUCTURE 上海海和药物研究开发股份有限公司 2023-04-06 WO disclosed
US-5559232-A ANTICOAGULANTS HOFFMANN-LA ROCHE INC. (US) 1996-09-24 US disclosed
US-5484954-A HEATING, DEACYLATING NIPPON KAYAKU KABUSHIKI KAISHA (JP) 1996-01-16 US disclosed
CN-1107839-A Carbox amide HOFFMANN LA ROCHE (CH) 1995-09-06 CN disclosed
EP-0641779-A1 Novel 1-amidinopiperdines and 4-amidinomorpholines as aggregation inhibitions F. HOFFMANN-LA ROCHE AG (CH) 1995-03-08 EP disclosed
US-5302730-A Acylation with acetic acid at positions one and seven; eliminating acyl group at position seven by solvolysis NIPPON KAYAKU KK (JP) 1994-04-12 US disclosed
EP-0297496-B1 Novel process for the preparation of 6,7-Diacyl-7-deacetylforskolin derivatives NIPPON KAYAKU KK (JP) 1994-01-19 EP disclosed
US-5245052-A PROCESS FOR PRODUCING 6-ACYL-7-DEACETYLFORSKOLIN DERIVATIVES NIPPON KAYAKU CO. LTD. (JP) 1993-09-14 US disclosed
EP-0469428-A1 Novel process for producing 6-acyl-7-deacetylforskolin derivatives HOECHST JAPAN LIMITED (JP) 1992-02-05 EP disclosed
EP-0297496-A2 Novel process for the preparation of 6,7-Diacyl-7-deacetylforskolin derivatives NIPPON KAYAKU KABUSHIKI KAISHA (JP) 1989-01-04 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12083124-B2 Bicyclic heterocycles as FGFR inhibitors FGFR1, FGFR3, FGFR2 HSD17B10 159/4885USP2 4138/4885ALDH1A1 559/4885
US-20260076982-A1 Prodrugs of Cannbidiol [CBD]-Type Phytocannabinoids and a Process for Preparation Thereof CNR1, CNR2, CBR1 HSD17B10 208/4885USP2 2638/4885ALDH1A1 1408/4885
US-20250057852-A1 BICYCLIC HETEROCYCLES AS FGFR INHIBITORS FGFR1, FGFR3, FGFR2 HSD17B10 159/4885USP2 4138/4885ALDH1A1 559/4885
US-20230338389-A1 BICYCLIC HETEROCYCLES AS FGFR INHIBITORS FGFR1, FGFR3, FGFR2 HSD17B10 159/4885USP2 4138/4885ALDH1A1 559/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.