Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29127812 | 0.71 | PDK2 (0.41) | BCHEACHE | |
| SCHEMBL15963988 | 0.68 | — | — | |
| SCHEMBL37753173 | 0.68 | NR1I2 (0.31) | — | |
| SCHEMBL31366252 | 0.68 | CYP17A1 (0.35) | — | |
| SCHEMBL23027852 | 0.67 | — | — | |
| SCHEMBL10716565 | 0.65 | CHRNB2 (0.37) | — | |
| SCHEMBL23082980 | 0.64 | TAAR1 (0.30) | — | |
| SCHEMBL14722340 | 0.63 | PDE10A (0.36) | — | |
| SCHEMBL13209315 | 0.62 | — | — | |
| SCHEMBL11862595 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3066082-B1 | 5,6,7,8-TETRAHYDRO-5,8-METHANOCINNOLINE DERIVATIVES AS RORC MODULATORS FOR THE TREATMENT OF AUTOIMMUNE DISEASES | HOFFMANN LA ROCHE (CH) | 2017-12-20 | — | — | EP | disclosed |
| EP-3066082-A1 | 5,6,7,8-TETRAHYDRO-5,8-METHANOCINNOLINE DERIVATIVES AS RORC MODULATORS FOR THE TREATMENT OF AUTOIMMUNE DISEASES | F. Hoffmann-La Roche AG (CH) | 2016-09-14 | — | — | EP | disclosed |
| EP-3066082-A1 | 5,6,7,8-TETRAHYDRO-5,8-METHANOCINNOLINE DERIVATIVES AS RORC MODULATORS FOR THE TREATMENT OF AUTOIMMUNE DISEASES | F. Hoffmann-La Roche AG (CH) | 2016-09-14 | — | — | EP | disclosed |
| CN-105705492-A | 5,6,7, 8-tetrahydro-5, 8-methanocinnoline derivatives as RORC modulators for the treatment of autoimmune diseases | 豪夫迈·罗氏有限公司 | 2016-06-22 | — | — | CN | disclosed |
| WO-2015067575-A1 | 5,6,7,8-TETRAHYDRO-5,8-METHANOCINNOLINE DERIVATIVES AS RORC MODULATORS FOR THE TREATMENT OF AUTOIMMUNE DISEASES | F. HOFFMANN-LA ROCHE AG (CH) | 2015-05-14 | — | — | WO | disclosed |
| WO-2015067575-A1 | 5,6,7,8-TETRAHYDRO-5,8-METHANOCINNOLINE DERIVATIVES AS RORC MODULATORS FOR THE TREATMENT OF AUTOIMMUNE DISEASES | F. HOFFMANN-LA ROCHE AG (CH) | 2015-05-14 | — | — | WO | disclosed |