Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 9/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | HTR3A | P46098 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | HTR1D | P28221 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | DHFR | P00374 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16711121 | 0.84 | PDPK1 (0.58) | HRH4KDM4EHTR3ALMNAUSP2 | |
| SCHEMBL16711108 | 0.81 | HRH4 (0.67) | HRH4HTR3ALMNAUSP2TSHR | |
| SCHEMBL16711109 | 0.81 | HRH4 (0.52) | HRH4KDM4EHTR3ALMNAUSP2 | |
| SCHEMBL16701393 | 0.80 | HRH4 (0.53) | HRH4HTR3ALMNAUSP2TSHR | |
| SCHEMBL4995148 | 0.78 | PIM1 (0.50) | HTR1AHTR2ADHFRMAPTCYP1A2 | |
| SCHEMBL4995101 | 0.78 | PIM1 (0.50) | HTR1AHTR2ADHFRMAPTCYP1A2 | |
| SCHEMBL5741120 | 0.76 | HRH4 (0.59) | HRH4KDM4ELMNAHTTHRH3 | |
| SCHEMBL3725420 | 0.76 | HSD17B10 (0.50) | HRH4KDM4ETSHRHSD17B10HTR1A | |
| SCHEMBL16711107 | 0.75 | HRH4 (0.48) | HRH4HTR3AHRH3HTR1AADRA2A | |
| SCHEMBL3725417 | 0.74 | SCN9A (0.54) | KDM4ELMNATSHRHTTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015069752-A9 | ACETYLCHOLINE BINDING PROTEIN LIGANDS, COOPERATIVE NACHR MODULATORS AND METHODS FOR MAKING AND USING | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2015-07-09 | — | — | WO | disclosed |
| WO-2015069752-A1 | ACETYLCHOLINE BINDING PROTEIN LIGANDS, COOPERATIVE NACHR MODULATORS AND METHODS FOR MAKING AND USING | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2015-05-14 | — | — | WO | disclosed |