Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 7/20 | 0.52 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.52 |
| ▸ | HTR3A | P46098 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | HTR1D | P28221 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16711121 | 0.91 | PDPK1 (0.58) | HRH4PDPK1HTR3AUSP2HTT | |
| SCHEMBL16701432 | 0.81 | HRH4 (0.52) | HRH4HTR3AHTR1AADRA2AADRA2C | |
| SCHEMBL16711108 | 0.79 | HRH4 (0.67) | HRH4PDPK1HTR3AHTR1AADRA2A | |
| SCHEMBL16701393 | 0.77 | HRH4 (0.53) | HRH4HTR3AHTR1AADRA2AADRA2C | |
| SCHEMBL16013548 | 0.76 | PIK3CA (0.48) | HSD17B10LMNATSHRAKT1PIK3CA | |
| SCHEMBL16701415 | 0.73 | CYP1A2 (0.78) | HRH4HRH3LMNARAF1BRAF | |
| SCHEMBL3724683 | 0.72 | BCHE (0.46) | PDPK1HTR2AHTR2CBCHEMAOA | |
| SCHEMBL16711107 | 0.72 | HRH4 (0.48) | HRH4HTR3AHTR1AADRA2AADRA2C | |
| SCHEMBL16013236 | 0.71 | NPC1 (0.50) | HRH4HTR1AADRA2AADRA2CHTR1D | |
| SCHEMBL603269 | 0.71 | HRH4 (0.69) | HRH4HTR3AHTR1AADRA2AADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015069752-A9 | ACETYLCHOLINE BINDING PROTEIN LIGANDS, COOPERATIVE NACHR MODULATORS AND METHODS FOR MAKING AND USING | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2015-07-09 | — | — | WO | disclosed |
| WO-2015069752-A1 | ACETYLCHOLINE BINDING PROTEIN LIGANDS, COOPERATIVE NACHR MODULATORS AND METHODS FOR MAKING AND USING | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2015-05-14 | — | — | WO | disclosed |