⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1670170 | 1.00 | — | — | |
| SCHEMBL15260093 | 1.00 | — | — | |
| Bromide SCHEMBL5420538 | 0.97 | — | — | |
| SCHEMBL20326800 | 0.73 | TSHR (0.31) | — | |
| SCHEMBL24934021 | 0.71 | — | — | |
| SCHEMBL19266821 | 0.71 | — | — | |
| Dimethylformamide SCHEMBL28155853 | 0.69 | — | — | |
| SCHEMBL359274 | 0.69 | — | — | |
| SCHEMBL9249509 | 0.67 | — | — | |
| SCHEMBL9249500 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 68 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12410179-B2 | Modulators of TNF alpha activity and uses thereof | RAYTHERA, INC. (US) | 2025-09-09 | — | — | US | disclosed |
| US-20250263418-A1 | MODULATORS OF TNF ALPHA ACTIVITY AND USES THEREOF | RAYTHERA, INC. | 2025-08-21 | — | — | US | disclosed |
| CN-119630670-A | Modulators of TNFalpha activity and uses thereof | 瑞雷拉公司 | 2025-03-14 | — | — | CN | disclosed |
| US-20250066375-A1 | MODULATORS OF TNF ALPHA ACTIVITY AND USES THEREOF | RAYTHERA, INC. | 2025-02-27 | — | — | US | disclosed |
| WO-2025038927-A1 | MODULATORS OF TNF ALPHA ACTIVITY AND USES THEREOF | RAYTHERA, INC. (US) | 2025-02-20 | — | — | WO | disclosed |
| EP-3080113-B1 | FUSED TRICYCLIC IMIDAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY | UCB BIOPHARMA SPRL (BE) | 2019-09-18 | — | — | EP | disclosed |
| US-10087179-B2 | Fused tricyclic imidazole derivatives as modulators of TNF activity | UCB BIOPHARMA SPRL (BE) | 2018-10-02 | — | — | US | disclosed |
| US-20170260178-A1 | ANTIBACTERIAL COMPOUNDS | SPERO GYRASE INC (US) | 2017-09-14 | — | — | US | disclosed |
| US-20170260178-A1 | ANTIBACTERIAL COMPOUNDS | SPERO GYRASE INC (US) | 2017-09-14 | — | — | US | disclosed |
| US-20170260178-A1 | ANTIBACTERIAL COMPOUNDS | SPERO GYRASE INC (US) | 2017-09-14 | — | — | US | disclosed |
| EP-2178375-A1 | PYRAZOLOÝ1,5-A¨PYRIMIDINE DERIVATIVES | Merck Sharp & Dohme Corp. (US) | 2010-04-28 | — | — | EP | disclosed |
| US-7534799-B2 | Pyridomorphinans, thienomorphinans and use thereof | SOUTHERN RESEARCH INSTITUTE (US) | 2009-05-19 | — | — | US | disclosed |
| WO-2009014620-A1 | PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES | MERCK & CO., INC. (US) | 2009-01-29 | — | — | WO | disclosed |
| WO-2009014620-A1 | PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES | MERCK & CO., INC. (US) | 2009-01-29 | — | — | WO | disclosed |
| US-7262199-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2007-08-28 | — | — | US | disclosed |
| US-7262199-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2007-08-28 | — | — | US | disclosed |
| US-20060264452-A1 | Pyridomorphinans, thienomorphinans and use thereof | SOUTHERN RESEARCH INSTITUTE (US) | 2006-11-23 | — | — | US | disclosed |
| US-7105675-B2 | Pyridomorphinans, thienomorphinans and use thereof | SOUTHERN RESEARCH INSTITUTE (US) | 2006-09-12 | — | — | US | disclosed |
| US-7015326-B1 | Pyridomorphinans, thienomorphinans and use thereof | SOUTHERN RESEARCH INSTITUTE (US) | 2006-03-21 | — | — | US | disclosed |
| US-20060047119-A1 | Pyridomorphinans, thienomorphinans and use thereof | SOUTHERN RESEARCH INSTITUTE (US) | 2006-03-02 | — | — | US | disclosed |