Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 6/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | ACP1 | P24666 | 1/20 | 0.37 |
| ▸ | PARG | Q86W56 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6888683 | 0.94 | CHRNA7 (0.46) | ADRA1AKCNH2HRH3CHRNA7KMT2A | |
| SCHEMBL1668780 | 0.90 | HRH3 (0.39) | ADRA1AKCNH2HRH3CHRNA7ALDH1A1 | |
| SCHEMBL6887461 | 0.88 | CHRNA7 (0.48) | ADRA1AKCNH2HRH3CHRNA7PARG | |
| SCHEMBL6887469 | 0.86 | CHRNA7 (0.43) | ADRA1AKCNH2HRH3CHRNA7ALDH1A1 | |
| SCHEMBL6888094 | 0.86 | KDM4E (0.44) | ADRA1AKCNH2HRH3CHRNA7KMT2A | |
| SCHEMBL6887435 | 0.86 | CHRNA7 (0.43) | ADRA1AKCNH2HRH3CHRNA7KMT2A | |
| SCHEMBL6887263 | 0.86 | CHRNA7 (0.43) | KCNH2CHRNA7KMT2AMEN1ALDH1A1 | |
| SCHEMBL6886841 | 0.84 | CHRNA7 (0.45) | KCNH2CHRNA7KMT2AALDH1A1MAPT | |
| SCHEMBL11905048 | 0.84 | CHRNA7 (0.41) | ADRA1AKCNH2HRH3CHRNA7KMT2A | |
| SCHEMBL6887525 | 0.83 | CHRNA7 (0.42) | ADRA1AKCNH2HRH3CHRNA7PARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488520-A1 | CONDENSED AZINE - DERIVATIVES FOR THE TREATMENT OF DISEASES RELATED TO THE ACETYLCHOLINE RECEPTOR | MSD Oss B.V. (NL) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011045258-A1 | CONDENSED AZINE - DERIVATIVES FOR THE TREATMENT OF DISEASES RELATED TO THE ACETYLCHOLINE RECEPTOR | N.V. ORGANON (NL) | 2011-04-21 | — | — | WO | disclosed |