Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 3/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.41 |
| ▸ | PARG | Q86W56 | 1/20 | 0.38 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | IDO2 | Q6ZQW0 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6888683 | 0.91 | CHRNA7 (0.46) | CHRNA7KCNH2ADRA1AHRH3PARG | |
| SCHEMBL6887461 | 0.90 | CHRNA7 (0.48) | CHRNA7KCNH2ADRA1AHRH3PARG | |
| SCHEMBL6888094 | 0.89 | KDM4E (0.44) | CHRNA7KCNH2ADRA1AHRH3PARG | |
| SCHEMBL6887469 | 0.89 | CHRNA7 (0.43) | CHRNA7KCNH2ADRA1AHRH3PARG | |
| SCHEMBL11905048 | 0.86 | CHRNA7 (0.41) | CHRNA7KCNH2ADRA1AHRH3PARG | |
| SCHEMBL1670209 | 0.86 | ADRA1A (0.42) | CHRNA7KCNH2ADRA1AHRH3PARG | |
| SCHEMBL6886312 | 0.86 | HPGD (0.40) | CHRNA7BRD4 | |
| SCHEMBL6887372 | 0.84 | CHRNA7 (0.47) | CHRNA7KCNH2ADRA1AHRH3PARG | |
| SCHEMBL6889957 | 0.84 | HRH3 (0.45) | CHRNA7KCNH2ADRA1AHRH3CHRNA1 | |
| SCHEMBL6889695 | 0.83 | CHRNA7 (0.38) | CHRNA7KCNH2CHRNA1CHRNB2CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011045258-A1 | CONDENSED AZINE - DERIVATIVES FOR THE TREATMENT OF DISEASES RELATED TO THE ACETYLCHOLINE RECEPTOR | N.V. ORGANON (NL) | 2011-04-21 | — | — | WO | disclosed |