Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDO2 | P48775 | 19/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16697694 | 0.95 | TDO2 (0.50) | TDO2 | |
| SCHEMBL16698030 | 0.88 | TDO2 (0.49) | TDO2GSK3BDYRK1A | |
| SCHEMBL16697903 | 0.86 | TDO2 (0.49) | TDO2 | |
| SCHEMBL16697865 | 0.86 | TDO2 (0.49) | TDO2 | |
| SCHEMBL16698147 | 0.85 | TDO2 (0.49) | TDO2 | |
| SCHEMBL16698272 | 0.83 | TDO2 (0.44) | TDO2 | |
| SCHEMBL16697783 | 0.79 | TDO2 (0.47) | TDO2 | |
| SCHEMBL16697882 | 0.79 | TDO2 (0.47) | TDO2 | |
| SCHEMBL16697781 | 0.79 | TDO2 (0.47) | TDO2 | |
| SCHEMBL16698397 | 0.79 | TDO2 (0.47) | TDO2GSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3066090-A1 | 4-(INDOL-3-YL)-PYRAZOLE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE | iTeos Therapeutics (BE) | 2016-09-14 | — | — | EP | claimed |
| WO-2015067782-A1 | 4-(INDOL-3-YL)-PYRAZOLE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE | ITEOS THERAPEUTICS (BE) | 2015-05-14 | — | — | WO | claimed |