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Sugi Predict / Targets / TDO2

TDO2

Tryptophan 2,3-dioxygenase · P48775 · TDO2 on Sugi Atlas →

94,066 patent compounds predicted against TDO2, 47,230 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL98309 SCHEMBL98309 0.74 20/20
SCHEMBL98113 SCHEMBL98113 0.64 18/20
SCHEMBL145885 SCHEMBL145885 0.57 14/20
SCHEMBL145745 SCHEMBL145745 0.56 11/20
SCHEMBL179163 SCHEMBL179163 0.53 9/20
SCHEMBL165798 SCHEMBL165798 0.42 8/20
SCHEMBL148082 SCHEMBL148082 0.49 7/20
SCHEMBL81312 SCHEMBL81312 0.41 7/20
Viridin Viridin (SCHEMBL150041) 0.37 7/20
Viridin Viridin (SCHEMBL150042) 0.37 7/20
SCHEMBL149958 SCHEMBL149958 0.51 6/20
Tanshinone I Tanshinone I (SCHEMBL244391) 0.48 6/20
SCHEMBL187169 SCHEMBL187169 0.44 6/20
SCHEMBL73865 SCHEMBL73865 0.70 5/20
SCHEMBL148203 SCHEMBL148203 0.65 5/20
SCHEMBL255900 SCHEMBL255900 0.45 5/20
SCHEMBL149285 SCHEMBL149285 0.75 4/20
SCHEMBL238277 SCHEMBL238277 0.60 4/20
SCHEMBL274178 SCHEMBL274178 0.53 4/20
SCHEMBL274179 SCHEMBL274179 0.53 4/20

Clinical trials — most relevant to TDO2 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Tryptophan MRI in People With Schizophrenia and Healthy Controls PHASE2/PHASE3COMPLETED
A Trial of CM-AT in Children With Autism With All Levels of FCT (The Blum Study) PHASE3COMPLETED
Biomarker Study of PDR001 in Combination With MCS110 in Gastric Cancer PHASE2UNKNOWN
Diclofenac Dose Response Study PHASE1RECRUITING
TSK (Tryptophan - Serotonin - Kynurenine) Biomarkers Assessment in Stroke nanCOMPLETED
Tryptophan Metabolism in Healthy Young Adults nanCOMPLETED
The Role of Dietary Tryptophan on Aryl Hydrocarbon Receptor Activation nanCOMPLETED
Genetic Variants Associated With Adolescent Suicide Attempts nanCOMPLETED
Anaesthesia and Tryptophan Pathway nanUNKNOWN
Evaluating a Personalised Online Program With Human Support for Women With Depression and Its Impact on Mental Health and Biological Changes nanNOT_YET_RECRUITING
Disturbances of Kynurenine Pathway of Trytophan Metabolism in Schizophrenia: A Quantitative Reverse Transcription Polymerase Chain Reaction (RT-PCR) Study nanCOMPLETED
Investigating Serotonin Signalling in IBD Patients nanRECRUITING
In Vivo Assessment of Histamine Pharmacodynamics nanWITHDRAWN
Molecular Epidemiology of Dioxin-Related Illness in Seveso nanCOMPLETED
Intestinal Microbiota, Tryptophan and Autism nanCOMPLETED
Markers of Pulmonary Dysbiosis Associated With Exacerbation in Patients Followed for Cystic Fibrosis nanUNKNOWN
Vancomycin Associated Red Man Syndrome (RMS) nanCOMPLETED
Assesment of Vitamin B6 Level in Patients With Major Depressive Disorder nanUNKNOWN
Hydroxyl Free Radical Associated Effects of SGLT-2 Inhibitors in Type 2 Diabetes nanCOMPLETED
Serotonin, Serotonin Genetics(TPH2) and Emotion and Interference Processing nanUNKNOWN
Iron Status in Children With ADHD nanNOT_YET_RECRUITING
Effect of Vitamin D Administration Along With SSRIs in Patients With Major Depressive Disorder nanUNKNOWN
Effects of Preoperative Oral Carbohydrate Loading on Maternal Thiol-disulfide Homeostasis nanCOMPLETED
Estrogen Receptor 1 Gene Polymorphism Frequency in Fibromyalgia Syndrome nanCOMPLETED
Expression of TET1 Gene in Acute Leukaemia nanUNKNOWN
A Study of Selenomethionine and Myo-inositol(SOLOWAYS_TM) in Patients With Autoimmune Thyroiditis Carrying the DIO2 Thr92Ala Polymorphism nanCOMPLETED
Biomarker for the Early Diagnosis and Monitoring in Tyrosinemia Type 1 (BioTyrosin) nanWITHDRAWN
Pharmacogenetic Determinants Of Treatment Response In Children nanRECRUITING
Impact of RIVP on GI Function in Patients Undergoing Surgical Repair for ATAAD nanUNKNOWN
Prevalence of High Plasmatic 3OMethyldopa Level in a Specific Population of Patients With a Symptomatology Compatible With AADC Deficiency nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a TDO2 binder may also engage these)

ProteinNameSimilarity
Q5EBG2 — 1.000 Q5EBG2 →
P21643 — 1.000 P21643 →
Q2KIQ5 — 1.000 Q2KIQ5 →
Q5U4U6 — 1.000 Q5U4U6 →
P48776 — 1.000 P48776 →
A7MBU6 — 0.999 A7MBU6 →
Q2LD53 — 0.999 Q2LD53 →
Q7SY53 — 0.998 Q7SY53 →
B4JKK1 — 0.994 B4JKK1 →
B4IDV8 — 0.993 B4IDV8 →
Q17P71 — 0.993 Q17P71 →
Q95NN1 — 0.992 Q95NN1 →
B3NVC6 — 0.992 B3NVC6 →
Q24630 — 0.992 Q24630 →
B3MQP7 — 0.992 B3MQP7 →
P20351 — 0.992 P20351 →
B4M818 — 0.992 B4M818 →
O77457 — 0.992 O77457 →
B4PYW0 — 0.991 B4PYW0 →
Q29I03 — 0.991 Q29I03 →
B4H4U3 — 0.989 B4H4U3 →
B4MSH7 — 0.989 B4MSH7 →
Q09474 — 0.989 Q09474 →
B4L629 — 0.988 B4L629 →
Q55DB4 — 0.987 Q55DB4 →
A8X7X9 — 0.986 A8X7X9 →
Q63AJ2 — 0.981 Q63AJ2 →
O08739 — 0.981 O08739 →
Q81PQ0 — 0.981 Q81PQ0 →
P10759 — 0.981 P10759 →