⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20943580 | 1.00 | — | — | |
| SCHEMBL16701322 | 0.91 | — | — | |
| SCHEMBL19101771 | 0.88 | EGLN2 (0.32) | — | |
| SCHEMBL20943594 | 0.87 | TMPRSS2 (0.33) | — | |
| SCHEMBL30873318 | 0.85 | — | — | |
| SCHEMBL16698825 | 0.81 | TMPRSS2 (0.33) | — | |
| SCHEMBL19778893 | 0.79 | EGLN2 (0.33) | — | |
| SCHEMBL19101821 | 0.78 | — | — | |
| SCHEMBL30873302 | 0.78 | — | — | |
| SCHEMBL25386594 | 0.76 | TMPRSS2 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068405-A1 | PYRROLO [1,2,F][1,2,4]TRIAZINES USEFUL FOR TREATING RESPIRATORY SYNCITIAL VIRUS INFECTIONS | Gilead Sciences, Inc. (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015069939-A1 | PYRROLO [1,2,F] [1,2,4] TRIAZINES USEFUL FOR TREATING RESPIRATORY SYNCITIAL VIRUS INFECTIONS | GILEAD SCIENCES, INC. (US) | 2015-05-14 | — | — | WO | disclosed |