Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 19/20 | 0.67 |
| ▸ | MAPT | P10636 | 14/20 | 0.67 |
| ▸ | GSK3A | P49840 | 6/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18107518 | 0.86 | GSK3B (0.66) | GSK3BMAPTGSK3A | |
| SCHEMBL16710985 | 0.81 | GSK3B (1.00) | GSK3BMAPTGSK3A | |
| SCHEMBL2379693 | 0.70 | PLK1 (0.49) | — | |
| SCHEMBL16701998 | 0.69 | GSK3B (0.52) | GSK3BMAPTGSK3A | |
| SCHEMBL16702781 | 0.68 | GSK3B (1.00) | GSK3BMAPTGSK3A | |
| SCHEMBL19417885 | 0.68 | GSK3B (0.63) | GSK3BMAPTGSK3A | |
| SCHEMBL2997220 | 0.67 | KDM4E (0.55) | MAPT | |
| SCHEMBL31354740 | 0.67 | MAP2K1 (0.48) | GSK3BMAPT | |
| SCHEMBL18107534 | 0.66 | GSK3B (0.65) | GSK3BMAPTGSK3A | |
| SCHEMBL16704172 | 0.66 | GSK3B (0.68) | GSK3BMAPTGSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3066092-A1 | SUBSTITUTED PYRIDINE DERIVATIVES USEFUL AS GSK-3 INHIBITORS | Bristol-Myers Squibb Company (US) | 2016-09-14 | — | — | EP | disclosed |
| WO-2015069593-A1 | SUBSTITUTED PYRIDINE DERIVATIVES USEFUL AS GSK-3 INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-05-14 | — | — | WO | disclosed |