SCHEMBL1670487

SCHEMBL1670487

NC(=O)C(c1ccc(F)cc1)c1ccc(-n2nc(C(F)(F)F)cc2C2CC2)cc1

nearest known ligand 0.54

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
CRACR2A Q9BSW2 15/20 0.54
ORAI1 Q96D31 4/20 0.49
PRCP P42785 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19308645 0.78 CRACR2A (0.53) CRACR2AORAI1PRCP
SCHEMBL1668441 0.77 CRACR2A (0.65) CRACR2AORAI1
SCHEMBL1880912 0.76 CRACR2A (0.56) CRACR2AORAI1
SCHEMBL1668003 0.76 CRACR2A (0.75) CRACR2AORAI1
SCHEMBL1671385 0.75 CRACR2A (0.55) CRACR2AORAI1
SCHEMBL18176588 0.74 PRCP (0.52) CRACR2AORAI1PRCP
SCHEMBL16827876 0.74 PRCP (0.53) CRACR2AORAI1PRCP
SCHEMBL16827874 0.74 PRCP (0.53) CRACR2AORAI1PRCP
SCHEMBL1667944 0.73 CRACR2A (0.56) CRACR2AORAI1
SCHEMBL626659 0.73 CRACR2A (0.56) CRACR2AORAI1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2509955-A1 PYRAZOLE DERIVATIVES AS MODULATORS OF CALCIUM RELEASE -ACTIVATED CALCIUM CHANNEL Rhizen Pharmaceuticals S.A. (CH) 2012-10-17 EP disclosed
WO-2011042797-A1 PYRAZOLE DERIVATIVES AS MODULATORS OF CALCIUM RELEASE -ACTIVATED CALCIUM CHANNEL ICOZEN THERAPEUTICS PVT. LTD. (IN) 2011-04-14 WO disclosed