Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRACR2A | Q9BSW2 | 9/20 | 0.55 |
| ▸ | ORAI1 | Q96D31 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KCNJ6 | P48051 | 4/20 | 0.41 |
| ▸ | KCNJ3 | P48549 | 4/20 | 0.41 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1670487 | 0.75 | CRACR2A (0.54) | CRACR2AORAI1 | |
| SCHEMBL1668597 | 0.73 | CRACR2A (0.52) | CRACR2AORAI1NPC1LMNATP53 | |
| SCHEMBL1671387 | 0.71 | CRACR2A (1.00) | CRACR2AORAI1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1879322 | 0.70 | CRACR2A (0.67) | CRACR2AORAI1LMNAKCNJ6KCNJ3 | |
| SCHEMBL28073682 | 0.70 | CRACR2A (0.51) | CRACR2AORAI1NPC1LMNATP53 | |
| SCHEMBL1666818 | 0.69 | CRACR2A (0.58) | CRACR2AORAI1LMNAPKM | |
| SCHEMBL23203519 | 0.69 | KCNJ6 (0.65) | NPC1LMNATP53PKMRAB9A | |
| SCHEMBL30672491 | 0.69 | NPC1 (0.51) | CRACR2ANPC1LMNATP53PKM | |
| SCHEMBL28073675 | 0.68 | CRACR2A (0.51) | CRACR2AORAI1KCNJ6KCNJ3 | |
| SCHEMBL1881601 | 0.68 | CRACR2A (1.00) | CRACR2AORAI1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2509955-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF CALCIUM RELEASE -ACTIVATED CALCIUM CHANNEL | Rhizen Pharmaceuticals S.A. (CH) | 2012-10-17 | — | — | EP | disclosed |
| WO-2011042797-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF CALCIUM RELEASE -ACTIVATED CALCIUM CHANNEL | ICOZEN THERAPEUTICS PVT. LTD. (IN) | 2011-04-14 | — | — | WO | disclosed |