Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.51 |
| ▸ | NPC1 | O15118 | 5/20 | 0.51 |
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | COMT | P21964 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17590206 | 0.80 | CYP3A4 (0.58) | SMN1; SMN2ALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL31357892 | 0.80 | SMN1; SMN2 (0.56) | SMN1; SMN2ALDH1A1NPC1RAB9AHPGD | |
| SCHEMBL427731 | 0.79 | SMN1; SMN2 (0.59) | SMN1; SMN2ALDH1A1NPC1RAB9AHPGD | |
| Hydrochloric Acid SCHEMBL3265116 | 0.78 | SMN1; SMN2 (0.58) | SMN1; SMN2ALDH1A1NPC1RAB9AHPGD | |
| SCHEMBL2093272 | 0.78 | ALDH1A1 (0.63) | SMN1; SMN2ALDH1A1NPC1RAB9AHPGD | |
| SCHEMBL1460907 | 0.76 | SMN1; SMN2 (0.56) | SMN1; SMN2ALDH1A1NPC1RAB9AHPGD | |
| SCHEMBL7688360 | 0.76 | SMN1; SMN2 (0.56) | SMN1; SMN2ALDH1A1NPC1RAB9AHPGD | |
| SCHEMBL427730 | 0.76 | SMN1; SMN2 (0.56) | SMN1; SMN2ALDH1A1NPC1RAB9AHPGD | |
| SCHEMBL19936405 | 0.74 | SMN1; SMN2 (0.54) | SMN1; SMN2ALDH1A1NPC1RAB9AHPGD | |
| SCHEMBL12731719 | 0.73 | SMN1; SMN2 (0.53) | SMN1; SMN2ALDH1A1NPC1RAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2549875-B1 | SOLUBLE GUANYLATE CYCLASE ACTIVATORS | MERCK SHARP & DOHME (US) | 2015-05-13 | — | — | EP | disclosed |