Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | NOS1 | P29475 | 5/20 | 0.40 |
| ▸ | NOS3 | P29474 | 4/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.39 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16705687 | 0.88 | BCHE (0.41) | SIGMAR1NOS1NOS3HTR2AKCNH2 | |
| SCHEMBL16705657 | 0.86 | GNE (0.46) | ALDH1A1CYP2D6TSHRTDP1FAAH | |
| SCHEMBL30319456 | 0.86 | GNE (0.46) | ALDH1A1CYP2D6TSHRTDP1FAAH | |
| SCHEMBL16705655 | 0.86 | GNE (0.46) | ALDH1A1CYP2D6TSHRTDP1FAAH | |
| SCHEMBL16705685 | 0.85 | HRH3 (0.39) | SIGMAR1HRH1HRH3NOS1NOS3 | |
| SCHEMBL18110236 | 0.85 | CYP2D6 (0.43) | HRH1HRH3MBTD1L3MBTL3L3MBTL1 | |
| SCHEMBL18110284 | 0.85 | CYP2D6 (0.43) | HRH1HRH3MBTD1L3MBTL3L3MBTL1 | |
| SCHEMBL16705714 | 0.85 | HRH3 (0.39) | SIGMAR1HRH1HRH3NOS1NOS3 | |
| SCHEMBL23219632 | 0.81 | GNE (0.50) | ALDH1A1CYP2D6TSHRTDP1FAAH | |
| SCHEMBL19524220 | 0.79 | GNE (0.40) | ALDH1A1CYP2D6TSHRTDP1FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10434199-B2 | Picolinate cross-bridged cyclams, chelates with metallic cations and use thereof | UNIVERSITÉ DE BRETAGNE OCCIDENTALE (FR) | 2019-10-08 | — | — | US | disclosed |
| EP-3068787-B1 | PICOLINATE CROSS-BRIDGED CYCLAMS, CHELATES WITH METALLIC CATIONS AND USE THEREOF | UNIVERSITÉ DE BRETAGNE OCCIDENTALE (FR) | 2017-11-01 | — | — | EP | disclosed |
| US-20160287733-A1 | PICOLINATE CROSS-BRIDGED CYCLAMS, CHELATES WITH METALLIC CATIONS AND USE THEREOF | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2016-10-06 | — | — | US | disclosed |
| US-20160287733-A1 | PICOLINATE CROSS-BRIDGED CYCLAMS, CHELATES WITH METALLIC CATIONS AND USE THEREOF | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2016-10-06 | — | — | US | disclosed |
| EP-2871186-B1 | Picolinate cross-bridged cyclams, chelates with metallic cations and use thereof | UNIVERSITÉ DE BRETAGNE OCCIDENTALE (FR) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015071334-A1 | PICOLINATE CROSS-BRIDGED CYCLAMS, CHELATES WITH METALLIC CATIONS AND USE THEREOF | UNIVERSITÉ DE BRETAGNE OCCIDENTALE (FR) | 2015-05-21 | — | — | WO | disclosed |
| EP-2871186-A1 | Picolinate cross-bridged cyclams, chelates with metallic cations and use thereof | Université de Bretagne Occidentale (FR) | 2015-05-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10434199-B2 | Picolinate cross-bridged cyclams, chelates with metallic cations and use thereof | SLC39A14, SLC67A1, SLC39A3 | SIGMAR1 947/4885HRH1 2401/4885HRH3 2116/4885 |
| US-20160287733-A1 | PICOLINATE CROSS-BRIDGED CYCLAMS, CHELATES WITH METALLIC CATIONS AND USE THEREOF | SLC39A14, SLC67A1, SLC39A3 | SIGMAR1 947/4885HRH1 2401/4885HRH3 2116/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.