Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 20/20 | 0.68 |
| ▸ | KIT | P10721 | 4/20 | 0.65 |
| ▸ | FLT3 | P36888 | 4/20 | 0.65 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.65 |
| ▸ | KDR | P35968 | 3/20 | 0.65 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.65 |
| ▸ | EGFR | P00533 | 1/20 | 0.65 |
| ▸ | MST1R | Q04912 | 1/20 | 0.65 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.62 |
| ▸ | FLT4 | P35916 | 1/20 | 0.62 |
| ▸ | AXL | P30530 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL697403 | 0.97 | MET (0.71) | METKITFLT3PDGFRAKDR | |
| SCHEMBL697892 | 0.95 | MET (0.74) | METKITFLT3PDGFRAKDR | |
| SCHEMBL15425895 | 0.91 | MET (0.66) | METKITFLT3PDGFRAKDR | |
| SCHEMBL168146 | 0.91 | MET (0.76) | METKITFLT3PDGFRAKDR | |
| SCHEMBL696346 | 0.91 | MET (0.74) | METKITFLT3PDGFRAKDR | |
| SCHEMBL698269 | 0.90 | MET (0.69) | METKITFLT3PDGFRAKDR | |
| SCHEMBL168678 | 0.90 | MET (0.73) | METKITFLT3PDGFRAKDR | |
| SCHEMBL167591 | 0.90 | MET (0.76) | METKITFLT3PDGFRAKDR | |
| SCHEMBL698314 | 0.89 | MET (0.64) | METKITFLT3PDGFRAKDR | |
| SCHEMBL167823 | 0.89 | MET (0.61) | METKITFLT3PDGFRAKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609091-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AS AXL INHIBITORS | Lead Discovery Center GmbH (DE) | 2013-07-03 | — | — | EP | claimed |
| WO-2012028332-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AS AXL INHIBITORS | LEAD DISCOVERY CENTER GMBH (DE) | 2012-03-08 | — | — | WO | claimed |