Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR88 | Q9GZN0 | 20/20 | 0.91 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1666650 | 1.00 | GPR88 (0.91) | GPR88SLC6A4OPRK1 | |
| SCHEMBL14877718 | 1.00 | GPR88 (0.91) | GPR88SLC6A4OPRK1 | |
| SCHEMBL12212381 | 0.92 | GPR88 (0.77) | GPR88SLC6A4OPRK1 | |
| SCHEMBL1666760 | 0.90 | GPR88 (0.91) | GPR88 | |
| SCHEMBL6888089 | 0.90 | GPR88 (0.91) | GPR88 | |
| SCHEMBL1667090 | 0.86 | GPR88 (0.91) | GPR88 | |
| SCHEMBL6888518 | 0.86 | GPR88 (0.91) | GPR88 | |
| SCHEMBL1666813 | 0.84 | GPR88 (0.70) | GPR88SLC6A4OPRK1 | |
| SCHEMBL1666815 | 0.84 | GPR88 (0.70) | GPR88SLC6A4OPRK1 | |
| SCHEMBL15145951 | 0.82 | GPR88 (0.64) | GPR88SLC6A4OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486014-A1 | MODULATORS OF G PROTEIN-COUPLED RECEPTOR 88 | Bristol-Myers Squibb Company (US) | 2012-08-15 | — | — | EP | disclosed |
| WO-2011044212-A1 | MODULATORS OF G PROTEIN-COUPLED RECEPTOR 88 | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-04-14 | — | — | WO | disclosed |