Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | STAT1 | P42224 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24554041 | 0.88 | TSHR (0.47) | TSHRALDH1A1HPGDGAAALOX15 | |
| SCHEMBL1194098 | 0.86 | MAPK1 (0.55) | TSHRALDH1A1HPGDGAACYP1A2 | |
| SCHEMBL13263371 | 0.84 | ALDH1A1 (0.47) | TSHRALDH1A1HPGDGAACYP1A2 | |
| SCHEMBL22658880 | 0.83 | TSHR (0.44) | TSHRALDH1A1HPGDGAACYP1A2 | |
| SCHEMBL29517486 | 0.83 | ALDH1A1 (0.46) | TSHRALDH1A1HPGDGAACYP1A2 | |
| SCHEMBL2826113 | 0.81 | TSHR (0.41) | TSHRALDH1A1HPGDGAACYP1A2 | |
| SCHEMBL18394517 | 0.80 | ALDH1A1 (0.44) | TSHRALDH1A1HPGDGAACYP1A2 | |
| SCHEMBL13224737 | 0.79 | SMN1; SMN2 (0.56) | TSHRALDH1A1HPGDGAACYP1A2 | |
| SCHEMBL31518545 | 0.79 | HPGD (0.46) | TSHRALDH1A1HPGDGAACYP1A2 | |
| SCHEMBL1564192 | 0.78 | TSHR (0.39) | TSHRALDH1A1HPGDGAACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9102637-B2 | Bicyclic thiazole compounds | CARNA BIOSCIENCES, INC. (JP) | 2015-08-11 | — | — | US | disclosed |
| US-20150133656-A1 | NOVEL BICYCLIC THIAZOLE COMPOUNDS | CARNA BIOSCIENCES INC. (JP) | 2015-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150133656-A1 | NOVEL BICYCLIC THIAZOLE COMPOUNDS | TNIK, TNNI3K, TNK1 | TSHR 2869/4885ALDH1A1 3946/4885HPGD 3589/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.