Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | KDM1A | O60341 | 4/20 | 0.36 |
| ▸ | MCHR2 | Q969V1 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6669198 | 0.78 | SIGMAR1 (0.38) | SIGMAR1KDM1AHTR2ADRD2SLC6A2 | |
| Hydrochloric Acid SCHEMBL6669828 | 0.72 | HTR2A (0.36) | SIGMAR1KDM1AHTR2ADRD2SLC6A2 | |
| SCHEMBL4975811 | 0.71 | MCHR2 (0.46) | SIGMAR1KDM1AMCHR2HTR2ADRD2 | |
| SCHEMBL30573675 | 0.71 | MCHR2 (0.46) | SIGMAR1KDM1AMCHR2HTR2ADRD2 | |
| Hydrochloric Acid SCHEMBL6668923 | 0.71 | HTR2A (0.35) | SIGMAR1KDM1AHTR2ADRD2SLC6A2 | |
| Hydrochloric Acid SCHEMBL6976186 | 0.70 | MCHR2 (0.45) | SIGMAR1KDM1AMCHR2HTR2ADRD2 | |
| Hydrochloric Acid SCHEMBL6973147 | 0.70 | MCHR2 (0.45) | SIGMAR1KDM1AMCHR2HTR2ADRD2 | |
| SCHEMBL21383813 | 0.70 | KDM1A (0.53) | SIGMAR1KDM1AHTR2ADRD2SLC6A2 | |
| SCHEMBL21920651 | 0.70 | KDM1A (0.53) | SIGMAR1KDM1AHTR2ADRD2SLC6A2 | |
| SCHEMBL29993139 | 0.70 | KDM1A (0.53) | SIGMAR1KDM1AHTR2ADRD2SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488500-A1 | SPIROPIPERIDINE COMPOUNDS AND PHARMACEUTICAL USE THEREOF FOR TREATING DIABETES | Eli Lilly and Company (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011046851-A1 | SPIROPIPERIDINE COMPOUNDS AND PHARMACEUTICAL USE THEREOF FOR TREATING DIABETES | ELI LILLY AND COMPANY (US) | 2011-04-21 | — | — | WO | disclosed |