Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 18/20 | 0.45 |
| ▸ | CBLB | Q13191 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 5/20 | 0.36 |
| ▸ | MYLK | Q15746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL233574 | 0.83 | MAP3K5 (0.53) | MAP3K5CBLBUSP30AKT1 | |
| SCHEMBL232935 | 0.82 | MAP3K5 (0.60) | MAP3K5AKT1 | |
| SCHEMBL235423 | 0.81 | MAP3K5 (0.48) | MAP3K5CBLBAKT1 | |
| SCHEMBL232728 | 0.79 | MAP3K5 (0.53) | MAP3K5AKT1 | |
| SCHEMBL234917 | 0.78 | MAP3K5 (0.50) | MAP3K5CBLBMYLK | |
| SCHEMBL235196 | 0.78 | MAP3K5 (0.48) | MAP3K5CBLBAKT1 | |
| SCHEMBL230573 | 0.73 | MAP3K5 (0.62) | MAP3K5AKT1MYLK | |
| SCHEMBL232980 | 0.73 | MAP3K5 (0.74) | MAP3K5AKT1 | |
| SCHEMBL16712434 | 0.72 | MAP3K5 (0.44) | MAP3K5AKT1 | |
| SCHEMBL233804 | 0.72 | MAP3K5 (0.59) | MAP3K5AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588475-B1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | GILEAD SCIENCES INC (US) | 2015-05-20 | — | — | EP | disclosed |