Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | PARP1 | P09874 | 1/20 | 0.50 |
| ▸ | GPR84 | Q9NQS5 | 5/20 | 0.46 |
| ▸ | PDE5A | O76074 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | XDH | P47989 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7887026 | 0.76 | ALDH1A1 (0.57) | ALDH1A1HTTSMN1; SMN2PDE5ARECQL | |
| SCHEMBL1586541 | 0.72 | PARP1 (0.91) | PARP1RAB9A | |
| SCHEMBL7883156 | 0.72 | PDE9A (0.49) | ALDH1A1HTTSMN1; SMN2RECQLNPC1 | |
| SCHEMBL4497867 | 0.71 | ALDH1A1 (0.57) | ALDH1A1HTTSMN1; SMN2PARP1RECQL | |
| SCHEMBL30176973 | 0.71 | PARP1 (0.89) | PARP1 | |
| SCHEMBL22857122 | 0.71 | PARP1 (0.89) | PARP1 | |
| SCHEMBL30176861 | 0.71 | PARP1 (0.89) | PARP1 | |
| SCHEMBL14621928 | 0.71 | PARP1 (0.89) | PARP1 | |
| SCHEMBL28598382 | 0.71 | PARP1 (0.89) | PARP1 | |
| SCHEMBL18284261 | 0.70 | HTT (0.54) | ALDH1A1HTTSMN1; SMN2PDE5ARECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2560962-B1 | INDAZOLE COMPOUNDS USEFUL AS KETOHEXOKINASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-05-20 | — | — | EP | disclosed |