Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 16/20 | 0.58 |
| ▸ | BTK | Q06187 | 2/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 13/20 | 0.50 |
| ▸ | PIK3CG | P48736 | 13/20 | 0.50 |
| ▸ | ABL1 | P00519 | 12/20 | 0.50 |
| ▸ | EGFR | P00533 | 12/20 | 0.50 |
| ▸ | HCK | P08631 | 12/20 | 0.50 |
| ▸ | SRC | P12931 | 12/20 | 0.50 |
| ▸ | KDR | P35968 | 12/20 | 0.50 |
| ▸ | PIK3CB | P42338 | 12/20 | 0.50 |
| ▸ | MTOR | P42345 | 12/20 | 0.50 |
| ▸ | EPHB4 | P54760 | 12/20 | 0.50 |
| ▸ | PRKDC | P78527 | 12/20 | 0.50 |
| ▸ | PI4KB | Q9UBF8 | 9/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.43 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.43 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16702031 | 0.85 | PIK3CD (0.58) | PIK3CDBTKPIK3CAPIK3CGABL1 | |
| SCHEMBL16702035 | 0.81 | PIK3CD (0.51) | PIK3CDBTKPIK3CAPIK3CGABL1 | |
| SCHEMBL23917454 | 0.79 | PIK3CD (0.65) | PIK3CDBTKPIK3CAPIK3CGABL1 | |
| SCHEMBL16712875 | 0.75 | PIK3CD (0.72) | PIK3CDBTKPIK3CAPIK3CGABL1 | |
| SCHEMBL16701439 | 0.74 | PIK3CD (1.00) | PIK3CDBTKPIK3CAPIK3CGABL1 | |
| SCHEMBL16702027 | 0.72 | PIK3CD (0.54) | PIK3CDBTKPIK3CAPIK3CGABL1 | |
| SCHEMBL14086589 | 0.69 | PIK3CD (0.76) | PIK3CDBTKPIK3CAPIK3CGABL1 | |
| SCHEMBL16655677 | 0.69 | PIK3CD (1.00) | PIK3CDBTKPIK3CAPIK3CGABL1 | |
| SCHEMBL16655580 | 0.69 | PIK3CD (0.67) | PIK3CDBTKPIK3CAPIK3CGABL1 | |
| SCHEMBL16701520 | 0.69 | PIK3CD (0.73) | PIK3CDBTKPIK3CGPIK3C2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160272645-A1 | Heterocyclic Compounds and Methods of Use | MEDIVATION TECHNOLOGIES, INC. (US) | 2016-09-22 | — | — | US | claimed |
| WO-2015069441-A1 | PYRAZOLO-, IMIDAZOLO- AND PYRROLO-PYRIDINE OR -PYRIMIDINE DERIVATIVES AS INHIBITORS O BRUTONS KINASE (BTK) | MEDIVATION TECHNOLOGIES, INC. (US) | 2015-05-14 | — | — | WO | claimed |
| US-20160272645-A1 | Heterocyclic Compounds and Methods of Use | MEDIVATION TECHNOLOGIES, INC. (US) | 2016-09-22 | — | — | US | disclosed |
| US-20160272645-A1 | Heterocyclic Compounds and Methods of Use | MEDIVATION TECHNOLOGIES, INC. (US) | 2016-09-22 | — | — | US | disclosed |
| US-20160272645-A1 | Heterocyclic Compounds and Methods of Use | MEDIVATION TECHNOLOGIES, INC. (US) | 2016-09-22 | — | — | US | disclosed |
| WO-2015069441-A1 | PYRAZOLO-, IMIDAZOLO- AND PYRROLO-PYRIDINE OR -PYRIMIDINE DERIVATIVES AS INHIBITORS O BRUTONS KINASE (BTK) | MEDIVATION TECHNOLOGIES, INC. (US) | 2015-05-14 | — | — | WO | disclosed |
| WO-2015069441-A1 | PYRAZOLO-, IMIDAZOLO- AND PYRROLO-PYRIDINE OR -PYRIMIDINE DERIVATIVES AS INHIBITORS O BRUTONS KINASE (BTK) | MEDIVATION TECHNOLOGIES, INC. (US) | 2015-05-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160272645-A1 | Heterocyclic Compounds and Methods of Use | BTK, PIK3CD, PIK3CB | PIK3CD 2/4885BTK 1/4885PIK3CA 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.