Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | CASP6 | P55212 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | CASP1 | P29466 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15058403 | 0.78 | RAB9A (0.47) | NPC1RAB9APOLBPDGFRBPDGFRA | |
| SCHEMBL11083139 | 0.78 | NPC1 (0.47) | NPC1RAB9APOLBPDGFRBPDGFRA | |
| SCHEMBL22411150 | 0.78 | NPC1 (0.40) | NPC1RAB9APOLBPDGFRBPDGFRA | |
| SCHEMBL5530115 | 0.78 | NPC1 (0.40) | NPC1RAB9APOLBPDGFRBPDGFRA | |
| SCHEMBL150476 | 0.78 | NPC1 (0.65) | NPC1RAB9APOLBPDGFRBPDGFRA | |
| SCHEMBL29350099 | 0.78 | NPC1 (0.65) | NPC1RAB9APOLBPDGFRBPDGFRA | |
| SCHEMBL15058270 | 0.76 | NPC1 (0.45) | NPC1RAB9APOLBPDGFRBPDGFRA | |
| SCHEMBL6647315 | 0.75 | NPC1 (0.62) | NPC1RAB9APOLBPDGFRBPDGFRA | |
| SCHEMBL13156510 | 0.73 | NPC1 (0.60) | NPC1RAB9APOLBPDGFRBPDGFRA | |
| SCHEMBL12532559 | 0.73 | NPC1 (0.60) | NPC1RAB9APOLBPDGFRBPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10639304-B2 | Kinase inhibitors | RAJASEKARAN AYYAPPAN K (US) | 2020-05-05 | — | — | US | disclosed |
| US-20170231975-A1 | Kinase Inhibitors | RAJASEKARAN AYYAPPAN K (US) | 2017-08-17 | — | — | US | disclosed |
| US-9636340-B2 | Kinase inhibitors | Rajasekaran, Ayyappan K. (US) | 2017-05-02 | — | — | US | disclosed |
| US-20150140071-A1 | KINASE INHIBITORS | RAJASEKARAN AYYAPPAN K (US) | 2015-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10639304-B2 | Kinase inhibitors | ABL1, SRC, ABL2 | NPC1 3135/4885RAB9A 1229/4885POLB 4158/4885 |
| US-20150140071-A1 | KINASE INHIBITORS | ABL1, SRC, ABL2 | NPC1 3135/4885RAB9A 1229/4885POLB 4158/4885 |
| US-20170231975-A1 | Kinase Inhibitors | ABL1, SRC, ABL2 | NPC1 3135/4885RAB9A 1229/4885POLB 4158/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.