SCHEMBL16715499

SCHEMBL16715499

CC(C)(C)c1ccc(CN2Cc3ccc(S(=O)(=O)Nc4ccc(F)cc4)cc3C2)cc1

nearest known ligand 0.81

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
MOGAT2 Q3SYC2 18/20 0.81
MEN1 O00255 1/20 0.47
NPC1 O15118 1/20 0.47
RAB9A P51151 1/20 0.47
KMT2A Q03164 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15435227 0.92 MOGAT2 (0.83) MOGAT2
SCHEMBL15435300 0.92 MOGAT2 (0.83) MOGAT2
SCHEMBL16715469 0.90 MOGAT2 (1.00) MOGAT2
SCHEMBL15435299 0.84 MOGAT2 (1.00) MOGAT2
SCHEMBL15399787 0.84 MOGAT2 (1.00) MOGAT2
SCHEMBL15435353 0.84 MOGAT2 (1.00) MOGAT2
SCHEMBL15435359 0.84 MOGAT2 (0.70) MOGAT2
SCHEMBL15435412 0.83 MOGAT2 (0.90) MOGAT2
SCHEMBL15435247 0.83 MOGAT2 (0.69) MOGAT2MEN1NPC1RAB9AKMT2A
SCHEMBL16715475 0.82 MOGAT2 (0.88) MOGAT2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2687507-B1 NITROGEN-CONTAINING CONDENSED HETEROCYCLIC COMPOUND TAISHO PHARMACEUTICAL CO LTD (JP) 2016-03-09 EP disclosed
US-9035059-B2 Nitrogen-containing condensed heterocyclic compound TAISHO PHARMACEUTICAL CO., LTD. (JP) 2015-05-19 US disclosed
US-9035059-B2 Nitrogen-containing condensed heterocyclic compound TAISHO PHARMACEUTICAL CO., LTD. (JP) 2015-05-19 US disclosed