Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 5/20 | 0.78 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.78 |
| ▸ | HTR6 | P50406 | 1/20 | 0.78 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.60 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.60 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.60 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.60 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.60 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.60 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.60 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.60 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | ATIC | P31939 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | PKLR | P30613 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL517779 | 0.88 | ESR1 (0.62) | ESR1CYP19A1HTR6HDAC3HDAC4 | |
| SCHEMBL5820194 | 0.88 | ESR1 (0.74) | ESR1CYP19A1HTR6HDAC3HDAC4 | |
| SCHEMBL4881882 | 0.86 | ESR1 (0.76) | ESR1CYP19A1HTR6HDAC3HDAC4 | |
| SCHEMBL16719349 | 0.85 | ESR1 (0.59) | ESR1CYP19A1HTR6HDAC3HDAC4 | |
| SCHEMBL3037102 | 0.85 | ESR1 (0.80) | ESR1CYP19A1HTR6HDAC3HDAC4 | |
| SCHEMBL16719422 | 0.84 | ESR1 (0.59) | ESR1CYP19A1HTR6HDAC3HDAC4 | |
| SCHEMBL16719591 | 0.84 | ESR1 (0.62) | ESR1CYP19A1HTR6HDAC3HDAC4 | |
| SCHEMBL16719616 | 0.84 | ESR1 (0.70) | ESR1CYP19A1HTR6HDAC3HDAC4 | |
| SCHEMBL7137662 | 0.83 | MEN1 (0.66) | ESR1CYP19A1HTR6HDAC3HDAC4 | |
| SCHEMBL19329860 | 0.82 | HTR6 (0.62) | ESR1CYP19A1HTR6HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |