Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.37 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 4/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.33 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16719562 | 0.88 | KMT2A (0.44) | KMT2ACDC7PKN1PKN2MEN1 | |
| SCHEMBL16719747 | 0.84 | KMT2A (0.64) | KMT2AMEN1CYP19A1APPMAPT | |
| SCHEMBL21812436 | 0.76 | KMT2A (0.47) | KMT2ACDC7PKN1PKN2MEN1 | |
| SCHEMBL31317829 | 0.76 | KMT2A (0.47) | KMT2ACDC7PKN1PKN2MEN1 | |
| SCHEMBL16719700 | 0.75 | FYN (0.44) | KMT2ACYP19A1APPFYN | |
| SCHEMBL16720520 | 0.75 | KMT2A (0.44) | KMT2AMEN1CYP19A1MAPTFYN | |
| SCHEMBL16719735 | 0.74 | METAP1 (0.42) | KMT2A | |
| SCHEMBL22004394 | 0.73 | KCNH2 (0.48) | KMT2ACDC7PKN1PKN2MEN1 | |
| SCHEMBL16720566 | 0.73 | BRAF (0.38) | KMT2AMEN1KCNH2 | |
| SCHEMBL16719938 | 0.71 | KMT2A (0.64) | KMT2AMEN1CYP19A1APPMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |