Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.39 |
| ▸ | MTOR | P42345 | 2/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.39 |
| ▸ | AHR | P35869 | 3/20 | 0.39 |
| ▸ | CMA1 | P23946 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | TYR | P14679 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18828549 | 0.80 | BACE1 (0.47) | S1PR1BRD4PIK3CAMTORPIK3CG | |
| SCHEMBL16719790 | 0.74 | BRD4 (0.44) | S1PR1BRD4PIK3CAMTORPIK3CG | |
| SCHEMBL16720139 | 0.74 | ADORA2A (0.42) | BRD4KDM4CPIK3CAMTORPIK3CG | |
| SCHEMBL9213361 | 0.72 | MAPT (0.51) | S1PR1BRD4KDM4CKDM4EALDH1A1 | |
| SCHEMBL16719604 | 0.71 | TYR (0.44) | BRD4KDM4CPIK3CAMTORPIK3CG | |
| SCHEMBL29142667 | 0.70 | BRD4 (0.43) | S1PR1BRD4PIK3CAMTORPIK3CG | |
| SCHEMBL16720408 | 0.70 | BACE1 (0.42) | BRD4PIK3CAMTORPIK3CGAHR | |
| SCHEMBL2460459 | 0.69 | S1PR1 (0.42) | S1PR1BRD4PIK3CAMTORPIK3CG | |
| SCHEMBL2463860 | 0.69 | BRD4 (0.49) | S1PR1BRD4PIK3CAMTORPIK3CG | |
| SCHEMBL16719829 | 0.69 | BRD4 (0.42) | BRD4KDM4CAHRCMA1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |