Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.41 |
| ▸ | AHR | P35869 | 3/20 | 0.41 |
| ▸ | CMA1 | P23946 | 1/20 | 0.41 |
| ▸ | TYR | P14679 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | CCNC | P24863 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3654046 | 0.75 | CYP1A2 (0.47) | NISCHMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL29445919 | 0.72 | BRAF (0.47) | BRD4APPAHRCMA1TYR | |
| SCHEMBL4786964 | 0.71 | AHR (0.49) | BRD4APPNISCHAHRCMA1 | |
| SCHEMBL18000228 | 0.70 | BRAF (0.58) | BRD4AHRCMA1TYRBRAF | |
| SCHEMBL6460701 | 0.70 | NISCH (0.53) | BRD4NISCHMEN1KMT2ADYRK1B | |
| SCHEMBL16719949 | 0.70 | ADORA2A (0.42) | BRD4APPNISCHAHRCMA1 | |
| SCHEMBL16720139 | 0.70 | ADORA2A (0.42) | BRD4APPNISCHAHRCMA1 | |
| SCHEMBL17626014 | 0.69 | KMO (0.49) | AHRMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL18828549 | 0.69 | BACE1 (0.47) | BRD4APPAHRCMA1TYR | |
| SCHEMBL27361728 | 0.69 | BRD4 (0.46) | BRD4APPAHRCMA1TYR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |