Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | PKM | P14618 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | GBA1 | P04062 | 2/20 | 0.49 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | MMP1 | P03956 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
| ▸ | MMP8 | P22894 | 1/20 | 0.45 |
| ▸ | MMP13 | P45452 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | IL1RN | P18510 | 1/20 | 0.44 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8349568 | 0.74 | ALDH1A1 (0.79) | ALDH1A1PKMLMNASMN1; SMN2KEAP1 | |
| SCHEMBL4664975 | 0.74 | ATM (0.55) | ALDH1A1PKMLMNASMN1; SMN2KEAP1 | |
| SCHEMBL4957448 | 0.73 | ATM (0.54) | ALDH1A1PKMLMNASMN1; SMN2KEAP1 | |
| SCHEMBL25334133 | 0.73 | ALDH1A1 (0.74) | ALDH1A1PKMLMNASMN1; SMN2KEAP1 | |
| SCHEMBL5450999 | 0.73 | ALDH1A1 (0.63) | ALDH1A1PKMLMNASMN1; SMN2KEAP1 | |
| SCHEMBL8881270 | 0.72 | ALDH1A1 (0.68) | ALDH1A1PKMLMNASMN1; SMN2KEAP1 | |
| SCHEMBL10453840 | 0.71 | ALDH1A1 (0.96) | ALDH1A1PKMLMNASMN1; SMN2KEAP1 | |
| SCHEMBL2371761 | 0.71 | ALDH1A1 (0.61) | ALDH1A1PKMLMNASMN1; SMN2KEAP1 | |
| SCHEMBL3651548 | 0.71 | ALDH1A1 (0.61) | ALDH1A1PKMLMNASMN1; SMN2KEAP1 | |
| SCHEMBL301743 | 0.71 | ALDH1A1 (0.67) | ALDH1A1PKMLMNASMN1; SMN2KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |