Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 3/20 | 0.39 |
| ▸ | DRD3 | P35462 | 3/20 | 0.39 |
| ▸ | HTR6 | P50406 | 3/20 | 0.39 |
| ▸ | RECQL | P46063 | 2/20 | 0.38 |
| ▸ | AVPR2 | P30518 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16719510 | 0.86 | MAPT (0.41) | MAPTALDH1A1TDP1POLBNOTUM | |
| SCHEMBL8340891 | 0.80 | HRH4 (0.41) | NOTUMDRD2DRD3HTR6ALOX15 | |
| SCHEMBL26683787 | 0.72 | CRBN (0.45) | MAPTALDH1A1NOTUMMEN1KMT2A | |
| SCHEMBL3999191 | 0.72 | MAPT (0.44) | MAPTALDH1A1POLBNOTUMMEN1 | |
| SCHEMBL2625792 | 0.72 | ALDH1A1 (0.50) | ALDH1A1NOTUMKMT2AHPGDDRD2 | |
| SCHEMBL6784076 | 0.71 | DRD3 (0.39) | MAPTNOTUMDRD2DRD3HTR6 | |
| SCHEMBL31443460 | 0.71 | CHRM2 (0.45) | ALDH1A1NOTUMDRD2NPC1RAB9A | |
| SCHEMBL2625797 | 0.71 | CHRM2 (0.45) | ALDH1A1NOTUMDRD2NPC1RAB9A | |
| SCHEMBL21761195 | 0.71 | NOTUM (0.43) | MAPTALDH1A1NOTUMMEN1KMT2A | |
| SCHEMBL30334948 | 0.71 | CYP1A2 (0.53) | NOTUMCYP1A2CYP2D6NPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |