Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.35 |
| ▸ | APLNR | P35414 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.33 |
| ▸ | VHL | P40337 | 1/20 | 0.33 |
| ▸ | ELOC | Q15369 | 1/20 | 0.33 |
| ▸ | ELOB | Q15370 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.32 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.31 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.31 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.31 |
| ▸ | MIF | P14174 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30201408 | 0.74 | MAPT (0.52) | POLBKDM4EALDH1A1ALKMAPT | |
| SCHEMBL12369610 | 0.74 | CHRNB2 (0.44) | CHRNB2CHRNA4POLBKDM4EHSD17B10 | |
| SCHEMBL5659919 | 0.74 | CHRNB2 (0.47) | CHRNB2CHRNA4POLBKDM4EALDH1A1 | |
| SCHEMBL30811828 | 0.74 | CHRNB2 (0.44) | CHRNB2CHRNA4POLBKDM4EMAPT | |
| SCHEMBL17819718 | 0.74 | VHL (0.52) | CHRNB2CHRNA4POLBKDM4EALK | |
| SCHEMBL31456616 | 0.74 | CA12 (0.40) | CHRNB2CHRNA4MAPTHSD17B1 | |
| SCHEMBL1423044 | 0.72 | HCAR2 (0.48) | CHRNB2CHRNA4POLBKDM4EALDH1A1 | |
| SCHEMBL29465138 | 0.70 | CYP2E1 (0.54) | CHRNB2CHRNA4CYP3A4CYP2A6 | |
| SCHEMBL29464651 | 0.70 | CHRNB2 (0.42) | CHRNB2CHRNA4POLBAPLNRKDM4E | |
| SCHEMBL3819587 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |