Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | HSD17B2 | P37059 | 8/20 | 0.37 |
| ▸ | HSD17B1 | P14061 | 7/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | ESR1 | P03372 | 3/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 2/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16720520 | 0.89 | KMT2A (0.44) | KMT2AKDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL16719938 | 0.83 | KMT2A (0.64) | KMT2AKDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL16719888 | 0.83 | FYN (0.44) | KMT2AALDH1A1CYP3A4CYP1A2FYN | |
| SCHEMBL20476664 | 0.80 | KMT2A (0.69) | KMT2AKDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL16719562 | 0.75 | KMT2A (0.44) | KMT2AMEN1MAPTFYN | |
| SCHEMBL16720916 | 0.72 | BRAF (0.38) | KMT2AMEN1 | |
| SCHEMBL16719700 | 0.71 | FYN (0.44) | KMT2AALDH1A1CYP3A4CYP1A2FYN | |
| SCHEMBL16719747 | 0.71 | KMT2A (0.64) | KMT2AKDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL3149942 | 0.70 | KMT2A (0.67) | KMT2AKDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL16719784 | 0.69 | HSD17B2 (0.43) | HSD17B2HSD17B1CYP3A4CYP2C9ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |