Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR5 | Q9H228 | 17/20 | 0.59 |
| ▸ | S1PR1 | P21453 | 15/20 | 0.59 |
| ▸ | S1PR3 | Q99500 | 4/20 | 0.54 |
| ▸ | LTK | P29376 | 1/20 | 0.51 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16722011 | 0.90 | S1PR1 (0.49) | S1PR5S1PR1S1PR3 | |
| SCHEMBL16722437 | 0.90 | S1PR5 (0.54) | S1PR5S1PR1S1PR3PDGFRA | |
| SCHEMBL15191985 | 0.89 | S1PR5 (0.56) | S1PR5S1PR1S1PR3LTKTAOK1 | |
| SCHEMBL16722188 | 0.88 | S1PR5 (0.56) | S1PR5S1PR1S1PR3LTKTAOK1 | |
| SCHEMBL16722014 | 0.88 | S1PR5 (0.54) | S1PR5S1PR1S1PR3 | |
| SCHEMBL16722681 | 0.88 | S1PR5 (0.56) | S1PR5S1PR1S1PR3PDGFRA | |
| SCHEMBL16722661 | 0.86 | S1PR5 (0.56) | S1PR5S1PR1S1PR3HTR2AKCNH2 | |
| SCHEMBL15191748 | 0.86 | S1PR5 (0.55) | S1PR5S1PR1S1PR3LTKTAOK1 | |
| SCHEMBL15191692 | 0.86 | S1PR5 (0.57) | S1PR5S1PR1S1PR3LTKTAOK1 | |
| SCHEMBL16722391 | 0.85 | S1PR5 (0.54) | S1PR5S1PR1S1PR3HTR2AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015073547-A1 | DISUBSTITUTED PHENOXY AZETIDINE DERIVATIVES AS SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR MODULATORS | ALLERGAN, INC. (US) | 2015-05-21 | — | — | WO | claimed |
| WO-2015073547-A1 | DISUBSTITUTED PHENOXY AZETIDINE DERIVATIVES AS SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR MODULATORS | ALLERGAN, INC. (US) | 2015-05-21 | — | — | WO | disclosed |
| WO-2015073547-A1 | DISUBSTITUTED PHENOXY AZETIDINE DERIVATIVES AS SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR MODULATORS | ALLERGAN, INC. (US) | 2015-05-21 | — | — | WO | disclosed |