Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRIM58 | Q8NG06 | 3/20 | 0.58 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12575960 | 0.86 | TRIM58 (0.56) | TRIM58MAP4K4NUDT1CYP1A2CYP3A4 | |
| SCHEMBL12575874 | 0.82 | TRIM58 (0.55) | TRIM58MAP4K4NUDT1MAPTALDH1A1 | |
| SCHEMBL16727526 | 0.82 | TRIM58 (0.48) | TRIM58MAP4K4NUDT1MAPTALDH1A1 | |
| SCHEMBL12575884 | 0.81 | TRIM58 (0.56) | TRIM58NUDT1MAPTALDH1A1LMNA | |
| SCHEMBL16727238 | 0.79 | MAPT (0.52) | MAP4K4MAPTTP53ALDH1A1LMNA | |
| SCHEMBL16727236 | 0.79 | MAP4K4 (0.56) | MAP4K4NUDT1ALDH1A1KMT2ACYP1A2 | |
| SCHEMBL16727237 | 0.78 | TRIM58 (0.50) | TRIM58MAP4K4NUDT1MAPTALDH1A1 | |
| SCHEMBL17803859 | 0.78 | TRIM58 (0.50) | TRIM58NUDT1MAPTALDH1A1KMT2A | |
| SCHEMBL17803860 | 0.78 | TRIM58 (0.50) | TRIM58MAP4K4NUDT1MAPTALDH1A1 | |
| SCHEMBL12575860 | 0.76 | TRIM58 (0.51) | TRIM58NUDT1MAPTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9359349-B2 | Substituted quinazolines as kinase inhibitors | INTELLIKINE LLC (US) | 2016-06-07 | — | — | US | disclosed |
| US-20150141442-A1 | CHEMICAL ENTITIES AND THERAPEUTIC USES THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2015-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150141442-A1 | CHEMICAL ENTITIES AND THERAPEUTIC USES THEREOF | PIK3CA, PIK3CB, PIK3C3 | TRIM58 2447/4885MAP4K4 135/4885NUDT1 1224/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.