TRIM58 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL8904733	0.56	8/20
SCHEMBL8908523	0.53	8/20
SCHEMBL8891165	0.55	7/20
SCHEMBL21055791	0.74	5/20
SCHEMBL8906282	0.56	5/20
SCHEMBL8910869	0.55	5/20
SCHEMBL8906810	0.52	5/20
SCHEMBL4355495	0.64	4/20
SCHEMBL13793916	0.59	4/20
SCHEMBL13650470	0.40	4/20
SCHEMBL14704794	0.37	4/20
SCHEMBL12365560	0.59	3/20
SCHEMBL16727240	0.58	3/20
SCHEMBL8899155	0.57	3/20
SCHEMBL8907323	0.57	3/20
SCHEMBL12575884	0.56	3/20
SCHEMBL12575960	0.56	3/20
SCHEMBL8901507	0.53	3/20
SCHEMBL8899135	0.53	3/20
SCHEMBL627593	0.52	3/20

Clinical trials — most relevant to TRIM58 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Can We Achieve 'high-quality' Weight Loss Through Supplementation and Exercise? the TRIM MUSCLE Study	PHASE3	COMPLETED
Effect of Deferoxamine on Wound Healing Rate in Patients With Diabetes Foot Ulcers	PHASE2	NOT_YET_RECRUITING
Phase II Study of Vandetanib in Individuals With Kidney Cancer	PHASE2	COMPLETED
3K3A-APC for Treatment of Amyotrophic Lateral Sclerosis (ALS)	PHASE2	COMPLETED
Phase II Prospective Cohort Study of Intravesical Recombinant Human Type 5 Adenovirus Injection for Treatment of High-Risk Non-Muscle Invasive Bladder Cancer: Evaluating Efficacy and Safety	PHASE2	NOT_YET_RECRUITING
PS-341 and Radiation to Treat Advanced Cancer of the Head and Neck	PHASE1	COMPLETED
A Study to Investigate the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of RO7248824 in Participants With Angelman Syndrome (AS)	PHASE1	COMPLETED
Impact of Nrf2 Activation on Macrovascular, Microvascular & Leg Function & Walking Capacity in Peripheral Artery Disease	EARLY_PHASE1	RECRUITING
Single-Dose AAV-MECP2 Safety/Tolerability and Efficacy in Rett Syndrome	EARLY_PHASE1	ACTIVE_NOT_RECRUITING
Clinical Study of 68Ga-DOTA-BLP PET Imaging in Noninvasive Diagnosis of Malignant Tumors	nan	NOT_YET_RECRUITING
Differential Gene Expression of Liver Tissue and Blood From Individuals With Chronic Viral Hepatitis	nan	UNKNOWN
Autophagy in Systemic Lupus Erythematosus	nan	UNKNOWN
The Role of RING Ubiquitin Ligases in Biologic and Oncologic Processes in Tissues of Mesenchymal Origin	nan	UNKNOWN
Signaling Pathways Targeting Colorectal Cancer in Egypt	nan	COMPLETED
Identification of a New Blood Biomarker for the Diagnosis and Prognosis of Liposarcomas	nan	RECRUITING
Mitochondrial Activity and Myosteatosis in the Cachexia of Cancers of the Upper Aerodigestive Tract	nan	UNKNOWN
Myotubular and Centronuclear Myopathy Patient Registry	nan	RECRUITING
Maximizing Mechanisms of Muscle Hypertrophy to Combat Sarcopenia in Older Adults	nan	COMPLETED
Exercise Therapy to Reduce Heart Failure Symptoms; Sorting Mechanisms of Benefit	nan	COMPLETED
Establishment of a Prospective Clinical-biological Database	nan	RECRUITING
Genetic Variation in TRAF3IP2 (rs13190932)	nan	RECRUITING
Diagnostic Potential of UCHL1 in Acute Decompensated Heart Failure	nan	COMPLETED
Gene Mutations and Rescue in Human Congenital Diaphragmatic Hernia	nan	UNKNOWN
18F-FDG PET/TC in TIR3A e TIR3B	nan	ENROLLING_BY_INVITATION
Long Term Follow-Up of Patients With Mesothelioma and Individuals With Germline Mutations in BAP1	nan	RECRUITING
Progressive Familial Intrahepatic Cholestasis in Indian Children - Establishing an Indian PFIC Registry	nan	UNKNOWN
Measuring Protein Turnover in Humans Across the Lifespan by Metabolic Labeling With Deuterium Oxide	nan	RECRUITING
Molecular Biomarkers Associated With Degenerative Joint Disease in the Knee	nan	COMPLETED
Family Blood Pressure Program - GenNet Network	nan	COMPLETED
Pleiotropy and Mechanism of Peripheral Nerve Related Genes in the Progression of Amyotrophic Lateral Sclerosis	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a TRIM58 binder may also engage these)

Protein	Name	Similarity
Q5NCC9	—	1.000	Q5NCC9 →
Q923T7	—	0.994	Q923T7 →
Q9C029	—	0.994	Q9C029 →
Q9TSW0	—	0.993	Q9TSW0 →
Q9WUH5	—	0.992	Q9WUH5 →
Q9C019	—	0.991	Q9C019 →
P19474	—	0.990	P19474 →
Q5TM55	—	0.990	Q5TM55 →
Q2T9Z0	—	0.989	Q2T9Z0 →
Q7YR33	—	0.989	Q7YR33 →
Q5E9G4	—	0.988	Q5E9G4 →
Q9Y577	—	0.987	Q9Y577 →
Q9WV59	—	0.986	Q9WV59 →
O77666	—	0.986	O77666 →
O19085	—	0.986	O19085 →
Q9UDY6	—	0.986	Q9UDY6 →
Q6AZZ1	—	0.986	Q6AZZ1 →
Q7TPM3	—	0.985	Q7TPM3 →
Q62158	—	0.984	Q62158 →
Q7YR32	—	0.983	Q7YR32 →
Q12899	—	0.982	Q12899 →
P14373	—	0.981	P14373 →
Q7YR34	—	0.979	Q7YR34 →
Q7YRV4	—	0.978	Q7YRV4 →
TRIM4	E3 ubiquitin-protein ligase TRIM4	0.978	landscape →
Q1XHU0	—	0.977	Q1XHU0 →
Q99PN3	—	0.976	Q99PN3 →
Q9HCM9	—	0.975	Q9HCM9 →
Q9ESN2	—	0.975	Q9ESN2 →
P62603	—	0.973	P62603 →