Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 11/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
| ▸ | STS | P08842 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20274569 | 1.00 | RORC (0.43) | RORCOPRD1OPRK1JAK2JAK1 | |
| SCHEMBL14805534 | 1.00 | RORC (0.43) | RORCOPRD1OPRK1JAK2JAK1 | |
| SCHEMBL16728431 | 0.89 | RORC (0.42) | RORCOPRD1OPRK1JAK2JAK1 | |
| SCHEMBL14805536 | 0.89 | RORC (0.42) | RORCOPRD1OPRK1JAK2JAK1 | |
| SCHEMBL14801926 | 0.86 | CYP2D6 (0.42) | KDM4EALDH1A1CYP2D6 | |
| SCHEMBL14801928 | 0.86 | CYP2D6 (0.42) | KDM4EALDH1A1CYP2D6 | |
| SCHEMBL14801925 | 0.86 | CYP2D6 (0.42) | KDM4EALDH1A1CYP2D6 | |
| SCHEMBL24276430 | 0.84 | RORC (0.46) | RORCOPRD1OPRK1JAK2JAK1 | |
| SCHEMBL18668635 | 0.84 | RORC (0.46) | RORCOPRD1OPRK1JAK2JAK1 | |
| SCHEMBL29597428 | 0.84 | RORC (0.46) | RORCOPRD1OPRK1JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9040547-B2 | Pyrrolopyrimidine and purine derivatives | PFIZER INC. (US) | 2015-05-26 | — | — | US | disclosed |