Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 1/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 7/20 | 0.44 |
| ▸ | JAK3 | P52333 | 7/20 | 0.44 |
| ▸ | JAK1 | P23458 | 4/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.44 |
| ▸ | ATR | Q13535 | 1/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.42 |
| ▸ | DPP4 | P27487 | 2/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.41 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.41 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.41 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 2/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16729338 | 1.00 | ACKR3 (0.46) | ACKR3CHRM4JAK2JAK3JAK1 | |
| SCHEMBL16729255 | 1.00 | ACKR3 (0.46) | ACKR3CHRM4JAK2JAK3JAK1 | |
| SCHEMBL16729253 | 0.96 | JAK2 (0.46) | ACKR3CHRM4JAK2JAK3JAK1 | |
| SCHEMBL16729261 | 0.95 | JAK2 (0.44) | ACKR3CHRM4JAK2JAK3JAK1 | |
| SCHEMBL16718898 | 0.94 | CHRM4 (0.50) | ACKR3CHRM4JAK2JAK3JAK1 | |
| Trifluoroacetic Acid SCHEMBL16718895 | 0.90 | DPP4 (0.49) | CHRM4JAK2JAK3JAK1KCNH2 | |
| SCHEMBL16718861 | 0.88 | ACKR3 (0.45) | ACKR3CHRM4JAK2JAK3JAK1 | |
| SCHEMBL16718884 | 0.84 | JAK2 (0.43) | ACKR3CHRM4JAK2JAK3JAK1 | |
| SCHEMBL16718864 | 0.83 | GRM4 (0.41) | ACKR3CHRM4JAK2JAK3JAK1 | |
| SCHEMBL16718850 | 0.82 | GRM4 (0.47) | ACKR3CHRM4JAK2JAK3JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015073267-A1 | SUBSTITUTED HETEROARYL COMPOUNDS AND METHODS OF USE | CALITOR SCIENCES, LLC (US) | 2015-05-21 | — | — | WO | disclosed |