Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.38 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.38 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.38 |
| ▸ | FASN | P49327 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 3/20 | 0.37 |
| ▸ | JAK3 | P52333 | 3/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16718861 | 0.95 | ACKR3 (0.45) | GRM4ACKR3CHRM4CHRM2CHRM5 | |
| SCHEMBL16718850 | 0.93 | GRM4 (0.47) | GRM4ACKR3CHRM4CHRM2CHRM5 | |
| SCHEMBL16718884 | 0.91 | JAK2 (0.43) | GRM4ACKR3CHRM4CHRM2CHRM5 | |
| SCHEMBL16729261 | 0.89 | JAK2 (0.44) | GRM4KMT2AACKR3MEN1CHRM4 | |
| SCHEMBL16729336 | 0.83 | ACKR3 (0.46) | GRM4ACKR3CHRM4DPP4DPP8 | |
| SCHEMBL16729255 | 0.83 | ACKR3 (0.46) | GRM4ACKR3CHRM4DPP4DPP8 | |
| SCHEMBL16729338 | 0.83 | ACKR3 (0.46) | GRM4ACKR3CHRM4DPP4DPP8 | |
| SCHEMBL16729339 | 0.83 | KDM4E (0.49) | GRM4CHRM4JAK2JAK3JAK1 | |
| SCHEMBL16718898 | 0.81 | CHRM4 (0.50) | GRM4ACKR3CHRM4JAK2JAK3 | |
| SCHEMBL16718874 | 0.79 | GRM4 (0.48) | GRM4KMT2AMEN1CHRM4BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015073267-A1 | SUBSTITUTED HETEROARYL COMPOUNDS AND METHODS OF USE | CALITOR SCIENCES, LLC (US) | 2015-05-21 | — | — | WO | disclosed |