SCHEMBL1673096

SCHEMBL1673096

Cc1cc(C(=O)CCc2sc(-c3ccc(C(F)(F)F)cc3)nc2C(C)C)ccc1OCC(=O)O

nearest known ligand 0.62

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
PPARD Q03181 20/20 0.62
PPARA Q07869 9/20 0.62
PPARG P37231 6/20 0.62
FFAR1 O14842 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2462565 0.93 PPARD (0.56) PPARDPPARAPPARGFFAR1
SCHEMBL4752343 0.92 PPARD (0.52) PPARDPPARAPPARGFFAR1
SCHEMBL4752363 0.92 PPARD (0.52) PPARDPPARAPPARG
SCHEMBL1672782 0.91 PPARD (0.51) PPARDPPARAPPARGFFAR1
SCHEMBL13386562 0.91 PPARD (0.53) PPARDPPARAPPARGFFAR1
SCHEMBL1765890 0.91 PPARD (0.53) PPARDPPARAPPARGFFAR1
SCHEMBL23870829 0.91 PPARD (0.51) PPARDPPARAPPARG
SCHEMBL30003494 0.91 PPARD (0.51) PPARDPPARAPPARG
SCHEMBL1765870 0.91 PPARD (0.49) PPARDPPARAPPARGFFAR1
SCHEMBL26197140 0.90 PPARD (0.51) PPARDPPARAPPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190255022-A1 WOUND-HEALING AGENT NIPPON CHEMIPHAR CO., LTD. (JP) 2019-08-22 US claimed
EP-3456327-A1 WOUND-HEALING AGENT Nippon Chemiphar Co., Ltd. (JP) 2019-03-20 EP claimed
US-9463185-B2 Pharmaceutical containing PPAR-delta agonist SENJU PHARMACEUTICAL CO., LTD. (JP) 2016-10-11 US claimed
US-20140343109-A1 PHARMACEUTICAL CONTAINING PPAR-delta AGONIST SENJU PHARMACEUTICAL CO., LTD. (JP) 2014-11-20 US claimed
US-8802705-B2 Pharmaceutical containing PPAR delta agonist SENJU PHARMACEUTICAL CO., LTD. (JP) 2014-08-12 US claimed
EP-2151438-B1 PHARMACEUTICAL CONTAINING PPAR-DELTA AGONIST SENJU PHARMA CO (JP) 2012-10-31 EP claimed
US-20120270910-A2 PHARMACEUTICAL CONTAINING PPAR-DELTA AGONIST SENJU PHARMACEUTICAL CO., LTD. (JP) 2012-10-25 US claimed
EP-1424330-B1 ACTIVATOR FOR PEROXISOME PROLIFERATOR-RESPONSIVE RECEPTOR DELTA NIPPON CHEMIPHAR CO (JP) 2011-09-28 EP claimed
US-20100190833-A1 PHARMACEUTICAL CONTAINING PPARA AGONIST SENJU PHARMACEUTICAL CO., LTD. (JP) 2010-07-29 US claimed
EP-2151438-A1 PHARMACEUTICAL CONTAINING PPAR AGONIST Senju Pharmaceutical Co., Ltd. (JP) 2010-02-10 EP claimed
US-10426757-B2 Compositions and methods for promoting intestinal stem cell and/or non-stem progenitor cell function WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) 2019-10-01 US disclosed
US-20190255022-A1 WOUND-HEALING AGENT NIPPON CHEMIPHAR CO., LTD. (JP) 2019-08-22 US disclosed
EP-3456327-A1 WOUND-HEALING AGENT Nippon Chemiphar Co., Ltd. (JP) 2019-03-20 EP disclosed
US-20180203025-A1 HDL THERAPY MARKERS CERENIS THERAPEUTICS HOLDING SA (FR) 2018-07-19 US disclosed
US-20170258772-A1 COMPOSITIONS AND METHODS FOR PROMOTING INTESTINAL STEM CELL AND/OR NON-STEM PROGENITOR CELL FUNCTION HOWARD HUGHES MEDICAL INSTITUTE 2017-09-14 US disclosed
US-20080009525-A1 Activator of peroxisome proliferator-activated receptor delta SAKUMA SHOGO 2008-01-10 US disclosed
US-20080009631-A1 Activator for peroxisome proliferator-activated receptor delta SAKUMA SHOGO 2008-01-10 US disclosed
US-7265137-B2 Activator of peroxisome proliferator-activated re-ceptor δ NIPPON CHEMIPHAR CO., LTD. (JP) 2007-09-04 US disclosed
US-20050054674-A1 Activator of peroxisome proliferator-activated receptor NIPPON CHEMIPHAR CO., LTD. (JP) 2005-03-10 US disclosed
EP-1424330-A1 ACTIVATOR FOR PEROXISOME PROLIFERATOR-RESPONSIVE RECEPTOR DELTA NIPPON CHEMIPHAR CO., LTD. (JP) 2004-06-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080009525-A1 Activator of peroxisome proliferator-activated receptor delta PPARG, PPARD, PPARA PPARD 2/4885PPARA 3/4885PPARG 1/4885
US-20190255022-A1 WOUND-HEALING AGENT PPARG, PPARA, PPARD PPARD 3/4885PPARA 2/4885PPARG 1/4885
US-10426757-B2 Compositions and methods for promoting intestinal stem cell and/or non-stem progenitor cell function FABP2, ALPG, ALPI PPARD 2842/4885PPARA 1257/4885PPARG 786/4885
US-20080009631-A1 Activator for peroxisome proliferator-activated receptor delta PPARG, PPARD, PPARA PPARD 2/4885PPARA 3/4885PPARG 1/4885
US-20180203025-A1 HDL THERAPY MARKERS APOB, HDLBP, PON1 PPARD 1433/4885PPARA 1319/4885PPARG 1886/4885
US-20120270910-A2 PHARMACEUTICAL CONTAINING PPAR-DELTA AGONIST PPARA, PPARD, PPARG PPARD 2/4885PPARA 1/4885PPARG 3/4885
US-20170258772-A1 COMPOSITIONS AND METHODS FOR PROMOTING INTESTINAL STEM CELL AND/OR NON-STEM PROGENITOR CELL FUNCTION FABP2, ALPG, ALPI PPARD 2842/4885PPARA 1257/4885PPARG 786/4885
US-20140343109-A1 PHARMACEUTICAL CONTAINING PPAR-delta AGONIST PPARA, PPARD, PPARG PPARD 2/4885PPARA 1/4885PPARG 3/4885
US-20050054674-A1 Activator of peroxisome proliferator-activated receptor PPARG, PPARD, PPARA PPARD 2/4885PPARA 3/4885PPARG 1/4885
US-20100190833-A1 PHARMACEUTICAL CONTAINING PPARA AGONIST PPARA, PPARD, PPARG PPARD 2/4885PPARA 1/4885PPARG 3/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.