SCHEMBL1673199

SCHEMBL1673199

Cc1cc(C)nc(N2CC3CCNCC32)n1

nearest known ligand 0.53

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 17/20 0.53
CHRNB4 P30926 17/20 0.53
CHRNA3 P32297 17/20 0.53
CHRNA4 P43681 17/20 0.53
HCRTR1 O43613 3/20 0.46
HCRTR2 O43614 3/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11900414 1.00 CHRNB2 (0.53) CHRNB2CHRNB4CHRNA3CHRNA4HCRTR1
SCHEMBL11900415 1.00 CHRNB2 (0.53) CHRNB2CHRNB4CHRNA3CHRNA4HCRTR1
SCHEMBL11900448 1.00 CHRNB2 (0.53) CHRNB2CHRNB4CHRNA3CHRNA4HCRTR1
SCHEMBL11901730 1.00 CHRNB2 (0.53) CHRNB2CHRNB4CHRNA3CHRNA4HCRTR1
SCHEMBL11900384 0.88 CHRNB2 (0.46) CHRNB2CHRNB4CHRNA3CHRNA4HCRTR1
SCHEMBL11900378 0.88 CHRNB2 (0.46) CHRNB2CHRNB4CHRNA3CHRNA4HCRTR1
SCHEMBL1672225 0.83 CHRNB2 (0.50) CHRNB2CHRNB4CHRNA3CHRNA4HCRTR1
SCHEMBL1673196 0.81 CHRNB2 (0.50) CHRNB2CHRNB4CHRNA3CHRNA4HCRTR1
SCHEMBL11900321 0.80 HCRTR1 (0.48) CHRNB2CHRNB4CHRNA3CHRNA4HCRTR1
SCHEMBL11900320 0.80 HCRTR1 (0.48) CHRNB2CHRNB4CHRNA3CHRNA4HCRTR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2491034-B1 FUSED HETEROCYCLIC COMPOUNDS AS OREXIN RECEPTOR MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2013-12-18 EP disclosed
EP-2491034-A1 FUSED HETEROCYCLIC COMPOUNDS AS OREXIN RECEPTOR MODULATORS Janssen Pharmaceutica, N.V. (BE) 2012-08-29 EP disclosed
WO-2011050200-A1 FUSED HETEROCYCLIC COMPOUNDS AS OREXIN RECEPTOR MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2011-04-28 WO disclosed