Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 15/20 | 0.46 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16735482 | 0.87 | CCR2 (0.49) | CCR2BRAFMAPTHTTALDH1A1 | |
| SCHEMBL16735455 | 0.73 | CCR2 (0.50) | CCR2BRAFMAPTHTTALDH1A1 | |
| SCHEMBL16735481 | 0.72 | CCR2 (0.51) | CCR2BRAFMAPTHTTALDH1A1 | |
| SCHEMBL19415718 | 0.70 | CCR2 (0.55) | CCR2BRAF | |
| SCHEMBL9930692 | 0.68 | CCR2 (0.78) | CCR2BRAFMAPTHTTMEN1 | |
| SCHEMBL16735456 | 0.68 | CCR2 (0.51) | CCR2BRAFMAPTHTTALDH1A1 | |
| SCHEMBL9936703 | 0.67 | CCR2 (0.67) | CCR2BRAFMAPTHTTMEN1 | |
| SCHEMBL7592227 | 0.67 | CCR2 (0.67) | CCR2BRAF | |
| SCHEMBL9930439 | 0.67 | CCR2 (0.71) | CCR2BRAFMAPTHTTMEN1 | |
| SCHEMBL19415719 | 0.67 | CCR2 (0.71) | CCR2BRAFMAPTHTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2955173-B1 | 1,2-BIS-SULFONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | ALLERGAN INC (US) | 2017-10-04 | — | — | EP | claimed |
| EP-2651901-B1 | NOVEL 1,2- BIS-SULFONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | ALLERGAN INC (US) | 2015-05-27 | — | — | EP | claimed |