Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 18/20 | 0.63 |
| ▸ | FER | P16591 | 1/20 | 0.52 |
| ▸ | JAK2 | O60674 | 5/20 | 0.51 |
| ▸ | LYN | P07948 | 5/20 | 0.51 |
| ▸ | ZAP70 | P43403 | 5/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.51 |
| ▸ | MAPK3 | P27361 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | JAK1 | P23458 | 1/20 | 0.51 |
| ▸ | JAK3 | P52333 | 1/20 | 0.51 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.51 |
| ▸ | BTK | Q06187 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25398537 | 1.00 | SYK (0.63) | SYKFERJAK2LYNZAP70 | |
| SCHEMBL25399836 | 0.93 | SYK (0.63) | SYKFERJAK2LYNZAP70 | |
| SCHEMBL1990020 | 0.90 | SYK (0.78) | SYKFERJAK2LYNZAP70 | |
| SCHEMBL26288007 | 0.90 | SYK (0.78) | SYKFERJAK2LYNZAP70 | |
| SCHEMBL16950115 | 0.90 | SYK (0.78) | SYKFERJAK2LYNZAP70 | |
| SCHEMBL25403128 | 0.87 | SYK (0.81) | SYKFERJAK2KCNH2MAPK3 | |
| SCHEMBL1985807 | 0.83 | SYK (0.78) | SYKFERJAK2KCNH2MAPK3 | |
| SCHEMBL1987715 | 0.82 | SYK (0.76) | SYKFERJAK2KCNH2MAPK3 | |
| SCHEMBL1987708 | 0.82 | SYK (0.76) | SYKFERJAK2KCNH2MAPK3 | |
| SCHEMBL12564463 | 0.82 | SYK (0.76) | SYKFERJAK2KCNH2MAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2516434-B1 | FUSED HETEROAROMATIC PYRROLIDINONES AS SYK INHIBITORS | TAKEDA PHARMACEUTICAL (JP) | 2015-05-27 | — | — | EP | disclosed |