Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 14/20 | 0.78 |
| ▸ | FER | P16591 | 6/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.54 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.54 |
| ▸ | JAK2 | O60674 | 3/20 | 0.46 |
| ▸ | LYN | P07948 | 2/20 | 0.46 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | CDC7 | O00311 | 1/20 | 0.45 |
| ▸ | PLK4 | O00444 | 1/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.45 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1990020 | 1.00 | SYK (0.78) | SYKFERKCNH2AURKBMAPK1 | |
| SCHEMBL16950115 | 1.00 | SYK (0.78) | SYKFERKCNH2AURKBMAPK1 | |
| SCHEMBL1985807 | 0.93 | SYK (0.78) | SYKFERKCNH2AURKBMAPK1 | |
| SCHEMBL1987708 | 0.92 | SYK (0.76) | SYKFERKCNH2AURKBMAPK1 | |
| SCHEMBL1987715 | 0.92 | SYK (0.76) | SYKFERKCNH2AURKBMAPK1 | |
| SCHEMBL12564463 | 0.92 | SYK (0.76) | SYKFERKCNH2AURKBMAPK1 | |
| SCHEMBL1987705 | 0.92 | SYK (0.76) | SYKFERKCNH2AURKBMAPK1 | |
| SCHEMBL25398537 | 0.90 | SYK (0.63) | SYKFERKCNH2AURKBMAPK1 | |
| SCHEMBL16735741 | 0.90 | SYK (0.63) | SYKFERKCNH2AURKBMAPK1 | |
| SCHEMBL1988631 | 0.89 | SYK (0.66) | SYKFERKCNH2AURKBMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230295171-A1 | FUSED HETEROAROMATIC PYRROLIDINONES | WELLS THERAPEUTICS, INC. | 2023-09-21 | — | — | US | disclosed |
| US-20230295171-A1 | FUSED HETEROAROMATIC PYRROLIDINONES | WELLS THERAPEUTICS, INC. | 2023-09-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230295171-A1 | FUSED HETEROAROMATIC PYRROLIDINONES | SYK, ZAP70, LYN | SYK 1/4885FER 62/4885KCNH2 3478/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.