Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BMI1 | P35226 | 9/20 | 0.49 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.36 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16747855 | 0.90 | BMI1 (0.51) | BMI1DHODHAGPAT2GRM5KCNH3 | |
| SCHEMBL16747853 | 0.87 | BMI1 (0.66) | BMI1DHODH | |
| SCHEMBL16739733 | 0.86 | BMI1 (0.65) | BMI1DHODHKCNH3 | |
| SCHEMBL16739765 | 0.86 | BMI1 (0.53) | BMI1DHODHAGPAT2SOS1 | |
| SCHEMBL16748005 | 0.83 | BMI1 (0.46) | BMI1DHODHAGPAT2SOS1 | |
| SCHEMBL15747577 | 0.79 | BMI1 (0.53) | BMI1DHODHAGPAT2SOS1 | |
| SCHEMBL16739935 | 0.79 | BMI1 (0.46) | BMI1DHODHGRM5 | |
| SCHEMBL18100922 | 0.79 | BMI1 (0.53) | BMI1DHODHAGPAT2 | |
| SCHEMBL16740143 | 0.78 | BMI1 (0.43) | BMI1 | |
| SCHEMBL16747852 | 0.77 | DHFR (0.43) | BMI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3071553-A1 | SUBSTITUTED PYRIDINE AND PYRAZINE BMI-1 INHIBITORS | PTC Therapeutics, Inc. (US) | 2016-09-28 | — | — | EP | disclosed |
| WO-2015076800-A1 | SUBSTITUTED PYRIDINE AND PYRAZINE BMI-1 INHIBITORS | PTC THERAPEUTICS, INC. (US) | 2015-05-28 | — | — | WO | disclosed |