Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 1/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | KMO | O15229 | 2/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.43 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | ATR | Q13535 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | CCNC | P24863 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16739630 | 0.81 | CDC7 (0.52) | CDC7CCNE1CDK2DBF4PARP1 | |
| SCHEMBL4776516 | 0.78 | PARP1 (0.52) | PARP1SCN9ASCN10APDK2CCNC | |
| SCHEMBL18229938 | 0.78 | CSNK1A1 (0.43) | CDC7CCNE1CDK2L3MBTL1PDK2 | |
| SCHEMBL6173681 | 0.75 | PARP1 (0.52) | PARP1SCN9ASCN10APDK2CCNC | |
| SCHEMBL12503020 | 0.75 | PARP1 (0.46) | CDC7CCNE1CDK2DBF4PARP1 | |
| SCHEMBL30502424 | 0.74 | HSD11B1 (0.49) | PARP1KMOSCN9ASCN10APDK2 | |
| SCHEMBL30673409 | 0.74 | PARP1 (0.51) | CDC7CCNE1CDK2DBF4PARP1 | |
| SCHEMBL5694519 | 0.74 | PARP1 (0.51) | CDC7CCNE1CDK2DBF4PARP1 | |
| SCHEMBL14062131 | 0.74 | CDC7 (0.46) | CDC7CCNE1CDK2PARP1L3MBTL1 | |
| SCHEMBL30290153 | 0.74 | PARP1 (0.45) | PARP1SCN9ASCN10AAURKARPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3071553-A1 | SUBSTITUTED PYRIDINE AND PYRAZINE BMI-1 INHIBITORS | PTC Therapeutics, Inc. (US) | 2016-09-28 | — | — | EP | disclosed |
| WO-2015076800-A1 | SUBSTITUTED PYRIDINE AND PYRAZINE BMI-1 INHIBITORS | PTC THERAPEUTICS, INC. (US) | 2015-05-28 | — | — | WO | disclosed |