Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 4/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.34 |
| ▸ | PIK3R1 | P27986 | 5/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16747893 | 0.76 | AGPAT2 (0.36) | MAP3K14PIK3CDPIK3R1PIK3CBPIK3CG | |
| SCHEMBL16740266 | 0.72 | BRAF (0.36) | CYP11B1CYP11B2 | |
| SCHEMBL16740076 | 0.71 | ABCG2 (0.34) | PIK3CDPIK3R1PIK3CBPIK3CGCYP11B2 | |
| SCHEMBL21518058 | 0.71 | ADORA2A (0.36) | MAP3K14PIK3CDPIK3R1NPC1MAPT | |
| SCHEMBL16550080 | 0.68 | BMI1 (0.42) | MAP3K14 | |
| SCHEMBL16747875 | 0.65 | PIK3CD (0.46) | MAP3K14PIK3CDPIK3R1PIK3CBPIK3CG | |
| SCHEMBL21518056 | 0.64 | PIK3CD (0.35) | GRM2PIK3CDALDH1A1GRIN2BPIK3CA | |
| SCHEMBL16540805 | 0.64 | CYP11B1 (0.32) | CYP11B1CYP11B2 | |
| SCHEMBL16540790 | 0.64 | CDK2 (0.40) | MAP3K14PIK3CDPIK3R1MAPTSMN1; SMN2 | |
| SCHEMBL21518059 | 0.64 | BMI1 (0.40) | GRM2PIK3CDGRIN2BCYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3071553-A1 | SUBSTITUTED PYRIDINE AND PYRAZINE BMI-1 INHIBITORS | PTC Therapeutics, Inc. (US) | 2016-09-28 | — | — | EP | claimed |
| WO-2015076800-A1 | SUBSTITUTED PYRIDINE AND PYRAZINE BMI-1 INHIBITORS | PTC THERAPEUTICS, INC. (US) | 2015-05-28 | — | — | WO | claimed |