Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BMI1 | P35226 | 2/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.34 |
| ▸ | MTOR | P42345 | 3/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.33 |
| ▸ | DHFR | P00374 | 1/20 | 0.32 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21518056 | 0.93 | PIK3CD (0.35) | BMI1PIK3CDPIK3CAMTORGRM2 | |
| SCHEMBL21518052 | 0.90 | BMI1 (0.42) | BMI1PIK3CDGRM2DHFRDCPS | |
| SCHEMBL21518066 | 0.90 | BMI1 (0.36) | BMI1PIK3CDPIK3CAMTORGRM2 | |
| SCHEMBL16541069 | 0.89 | ALDH1A1 (0.39) | PIK3CDPIK3CAMTORDHFR | |
| SCHEMBL21518060 | 0.87 | BMI1 (0.50) | BMI1PIK3CDPIK3CAMTORDHFR | |
| SCHEMBL16540828 | 0.83 | LCK (0.38) | PIK3CDPIK3CAMTORHDAC1HDAC8 | |
| SCHEMBL17938230 | 0.80 | MAP3K14 (0.44) | PIK3CDPIK3CAMTORDHFRRPS6KA5 | |
| SCHEMBL16540268 | 0.79 | BMI1 (0.38) | BMI1PIK3CDPIK3CAMTORDHFR | |
| SCHEMBL16541004 | 0.79 | L3MBTL1 (0.43) | PIK3CADHFR | |
| SCHEMBL17938228 | 0.79 | BMI1 (0.40) | BMI1DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3039015-B1 | SUBSTITUTED PYRIMIDINE BMI-1 INHIBITORS | PTC THERAPEUTICS INC (US) | 2019-10-30 | — | — | EP | claimed |
| EP-3039015-B1 | SUBSTITUTED PYRIMIDINE BMI-1 INHIBITORS | PTC THERAPEUTICS INC (US) | 2019-10-30 | — | — | EP | disclosed |